2016
Oncogenic EGFR Represses the TET1 DNA Demethylase to Induce Silencing of Tumor Suppressors in Cancer Cells
Forloni M, Gupta R, Nagarajan A, Sun LS, Dong Y, Pirazzoli V, Toki M, Wurtz A, Melnick MA, Kobayashi S, Homer RJ, Rimm DL, Gettinger SJ, Politi K, Dogra SK, Wajapeyee N. Oncogenic EGFR Represses the TET1 DNA Demethylase to Induce Silencing of Tumor Suppressors in Cancer Cells. Cell Reports 2016, 16: 457-471. PMID: 27346347, PMCID: PMC4945411, DOI: 10.1016/j.celrep.2016.05.087.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdenocarcinoma of LungAntineoplastic AgentsBrain NeoplasmsCCAAT-Enhancer-Binding ProteinsCell Line, TumorCpG IslandsDNA MethylationDrug Screening Assays, AntitumorErbB ReceptorsGene Expression Regulation, NeoplasticGene SilencingGlioblastomaHumansLung NeoplasmsMAP Kinase Signaling SystemMixed Function OxygenasesMutationOncogenesProtein Kinase InhibitorsProto-Oncogene ProteinsTranscription, GeneticTumor Suppressor ProteinsUp-RegulationConceptsOncogenic epidermal growth factor receptorMethylation-mediated transcriptional silencingEpidermal growth factor receptorTumor suppressorTranscriptional silencingActive DNA demethylationCancer cellsFamily member 1TET1 knockdownDNA demethylaseDNA demethylationTranscription factorsGrowth factor receptorEctopic expressionCytoplasmic localizationGlioblastoma tumor growthLung cancer cellsTET1 expressionFunctional roleSuppressorFactor receptorMember 1TET1SilencingLung cancer samples
1999
Role of Tissue Factor in Metastasis: Functions of the Cytoplasmic and Extracellular Domains of the Molecule
Bromberg ME, Sundaram R, Homer RJ, Garen A, Konigsberg WH. Role of Tissue Factor in Metastasis: Functions of the Cytoplasmic and Extracellular Domains of the Molecule. Thrombosis And Haemostasis 1999, 82: 88-92. PMID: 10456459, DOI: 10.1055/s-0037-1614634.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsGene Expression Regulation, NeoplasticHumansMelanomaMiceMice, SCIDMutationNeoplasm MetastasisRabbitsThromboplastinTumor Cells, CulturedConceptsCytoplasmic domainExtracellular domainTF-VIIa complexMetastatic effectsMelanoma cellsSerine residuesTF mutantsTF actsKey residuesMutant formsTissue factorMelanoma cell linesTransmembrane glycoproteinHuman melanoma cellsHuman melanoma cell linesVascularization of tumorsCell linesBlood coagulationPhosphorylationGrowth factorTF expressionVascular endothelial growth factorExpressionResiduesMelanoma lines