Role of Tissue Factor in Metastasis: Functions of the Cytoplasmic and Extracellular Domains of the Molecule
Bromberg ME, Sundaram R, Homer RJ, Garen A, Konigsberg WH. Role of Tissue Factor in Metastasis: Functions of the Cytoplasmic and Extracellular Domains of the Molecule. Thrombosis And Haemostasis 1999, 82: 88-92. PMID: 10456459, DOI: 10.1055/s-0037-1614634.Peer-Reviewed Original ResearchConceptsCytoplasmic domainExtracellular domainTF-VIIa complexMetastatic effectsMelanoma cellsSerine residuesTF mutantsTF actsKey residuesMutant formsTissue factorMelanoma cell linesTransmembrane glycoproteinHuman melanoma cellsHuman melanoma cell linesVascularization of tumorsCell linesBlood coagulationPhosphorylationGrowth factorTF expressionVascular endothelial growth factorExpressionResiduesMelanoma lines