Preparation, characterization, and evaluation of a monoclonal antibody against the rabbit platelet glycoprotein IIb/IIIa in an experimental angioplasty model.
Azrin MA, Ling FS, Chen Q, Pawashe A, Migliaccio F, Homer R, Todd M, Ezekowitz MD. Preparation, characterization, and evaluation of a monoclonal antibody against the rabbit platelet glycoprotein IIb/IIIa in an experimental angioplasty model. Circulation Research 1994, 75: 268-277. PMID: 8033340, DOI: 10.1161/01.res.75.2.268.Peer-Reviewed Original ResearchConceptsAntibody-treated groupBalloon angioplastyPlatelet inhibitionLuminal diameterPlatelet glycoprotein IIb/IIIa receptorControl groupGlycoprotein IIb/IIIa receptorIIb/IIIa receptorMonoclonal antibodiesPlatelet glycoprotein IIb/IIIaPotent platelet inhibitionMinimum luminal diameterInhibits platelet functionPathogenesis of restenosisGlycoprotein IIb/IIIaInfusion of salineSignificant differencesDeposition of plateletsIIb/IIIaQuantitative histological analysisSingle infusionVascular injurySecond infusionExperimental atherosclerosisFemoral artery