A Critical Role of SHP-1 in Regulation of Type 2 Inflammation in the Lung
Oh SY, Zheng T, Kim YK, Cohn L, Homer RJ, McKenzie AN, Zhu Z. A Critical Role of SHP-1 in Regulation of Type 2 Inflammation in the Lung. American Journal Of Respiratory Cell And Molecular Biology 2008, 40: 568-574. PMID: 18952567, PMCID: PMC2677436, DOI: 10.1165/rcmb.2008-0225oc.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBronchial HyperreactivityBronchoalveolar Lavage FluidCytokinesEpitheliumHypertrophyLungLymphocyte ActivationMetaplasiaMiceMice, Inbred C57BLMucin 5ACMucusPneumoniaProtein Tyrosine Phosphatase, Non-Receptor Type 6Pulmonary FibrosisSignal TransductionSTAT6 Transcription FactorTh2 CellsConceptsSHP-1Src homology 2 domain-containing protein tyrosine phosphataseProtein tyrosine phosphataseGene deletion approachIL-4/ILViable motheaten miceMev miceCritical roleTyrosine phosphataseKey genesNegative regulatorSignal transducerMolecular mechanismsCytokine receptorsMotheaten miceTranscription 6Critical moleculesDirect roleType 2 inflammationChronic inflammatory disordersHallmark of asthmaLung homeostasisPathwayGrowth factorAirway hyperresponsiveness