Th2-induced airway mucus production is dependent on IL-4Ralpha, but not on eosinophils.
Cohn L, Homer RJ, MacLeod H, Mohrs M, Brombacher F, Bottomly K. Th2-induced airway mucus production is dependent on IL-4Ralpha, but not on eosinophils. The Journal Of Immunology 1999, 162: 6178-83. PMID: 10229862, DOI: 10.4049/jimmunol.162.10.6178.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, InhalationAnimalsAsthmaBronchiEosinophiliaEosinophilsInterleukin-13 Receptor alpha1 SubunitInterleukin-4Interleukin-5Mast CellsMiceMice, Inbred BALB CMice, Inbred C57BLMice, Mutant StrainsMice, TransgenicMucusOvalbuminReceptors, InterleukinReceptors, Interleukin-13Receptors, Interleukin-4Th2 CellsConceptsMucus productionTh2 cellsAirway eosinophiliaAirway inflammationIL-4RalphaAirway mucus productionCD4 Th2 cellsAirway obstructionBAL eosinophiliaHuman asthmaticsMucus hyperproductionClinical symptomsIL-13Recipient miceTh1 cellsIL-4IL-5Respiratory tractEosinophiliaMast cellsAnimal modelsEosinophilsMarked increaseCell stimulationMucus