1983
Modulation of fluoropyrimidine metabolism in L1210 cells by l-alanosine
Heimer R, Goldberg D, Cadman E. Modulation of fluoropyrimidine metabolism in L1210 cells by l-alanosine. Biochemical Pharmacology 1983, 32: 199-206. PMID: 6870949, DOI: 10.1016/0006-2952(83)90544-0.Peer-Reviewed Original Research
1981
The influence of methotrexate pretreatment on 5-fluorouracil metabolism in L1210 cells.
Cadman E, Heimer R, Benz C. The influence of methotrexate pretreatment on 5-fluorouracil metabolism in L1210 cells. Journal Of Biological Chemistry 1981, 256: 1695-1704. PMID: 6161926, DOI: 10.1016/s0021-9258(19)69863-7.Peer-Reviewed Original ResearchConceptsMethotrexate pretreatmentConversion of FUraAddition of leucovorinSynergistic antitumor activityAbility of methotrexateTimes control valuesL1210 cellsEnhancement of intracellularSynergistic cell killingSoft agar cloningMethotrexate treatmentAntipurine effectMethotrexateConcentrations of methotrexateMaximal inhibitionControl valuesIntracellular methotrexateFUraInhibitory effectAntitumor activityExact mechanismIntracellular accumulationAgar cloningSimilar elevationsMicroM methotrexate