1983
Modulation of fluoropyrimidine metabolism in L1210 cells by l-alanosine
Heimer R, Goldberg D, Cadman E. Modulation of fluoropyrimidine metabolism in L1210 cells by l-alanosine. Biochemical Pharmacology 1983, 32: 199-206. PMID: 6870949, DOI: 10.1016/0006-2952(83)90544-0.Peer-Reviewed Original Research
1981
Effect of de novo purine synthesis inhibitors on 5-fluorouracil metabolism and cytotoxicity
Cadman E, Benz C, Heimer R, O'Shaughnessy J. Effect of de novo purine synthesis inhibitors on 5-fluorouracil metabolism and cytotoxicity. Biochemical Pharmacology 1981, 30: 2469-2472. PMID: 21043247, DOI: 10.1016/0006-2952(81)90343-9.Peer-Reviewed Original ResearchConceptsSynergistic cytotoxicityEffect of methotrexateActivity of methotrexatePurine synthesis inhibitorsMethotrexate pretreatmentPurine synthesisControl levelsIntracellular elevationL-alanosineIntracellular accumulationGlutamine antagonistMethotrexateL1210 cellsSynthesis inhibitorInhibitorsCytotoxicityDe novo purineL-norleucineMetabolismAntagonist