1986
Modulation of 5-Fluorouracil Cytotoxicity by Intracellular Pools of 5-Phosphoribosyl-1-Pyrophosphate (PRPP)
Benz C, Heimer R, Cadman E. Modulation of 5-Fluorouracil Cytotoxicity by Intracellular Pools of 5-Phosphoribosyl-1-Pyrophosphate (PRPP). Developments In Oncology 1986, 93-105. DOI: 10.1007/978-1-4613-2331-0_5.Peer-Reviewed Original Research
1985
Lack of enhanced cytotoxicity of cultured L1210 cells using folinic acid in combination with sequential methotrexate and fluorouracil
Danhauser L, Heimer R, Cadman E. Lack of enhanced cytotoxicity of cultured L1210 cells using folinic acid in combination with sequential methotrexate and fluorouracil. Cancer Chemotherapy And Pharmacology 1985, 15: 214-219. PMID: 3876889, DOI: 10.1007/bf00263888.Peer-Reviewed Original ResearchConceptsSequential methotrexateΜM methotrexateL1210 cellsSynergistic cell killingCultured L1210 cellsFolinic acidMTX pretreatmentMethotrexateL1210 cell growthAcid-precipitable materialHuman neoplasmsPresence of methotrexateFUraInhibitory effectElevated levelsEnhanced cytotoxicityCell killingCell fractionCytotoxicityDUrd incorporationInhibitionThymidylate synthetaseCell growthThymidylate synthesisCultured cells
1983
Modulation of fluoropyrimidine metabolism in L1210 cells by l-alanosine
Heimer R, Goldberg D, Cadman E. Modulation of fluoropyrimidine metabolism in L1210 cells by l-alanosine. Biochemical Pharmacology 1983, 32: 199-206. PMID: 6870949, DOI: 10.1016/0006-2952(83)90544-0.Peer-Reviewed Original Research
1981
Effect of de novo purine synthesis inhibitors on 5-fluorouracil metabolism and cytotoxicity
Cadman E, Benz C, Heimer R, O'Shaughnessy J. Effect of de novo purine synthesis inhibitors on 5-fluorouracil metabolism and cytotoxicity. Biochemical Pharmacology 1981, 30: 2469-2472. PMID: 21043247, DOI: 10.1016/0006-2952(81)90343-9.Peer-Reviewed Original ResearchConceptsSynergistic cytotoxicityEffect of methotrexateActivity of methotrexatePurine synthesis inhibitorsMethotrexate pretreatmentPurine synthesisControl levelsIntracellular elevationL-alanosineIntracellular accumulationGlutamine antagonistMethotrexateL1210 cellsSynthesis inhibitorInhibitorsCytotoxicityDe novo purineL-norleucineMetabolismAntagonist