2017
Brain‐responsive neurostimulation in patients with medically intractable seizures arising from eloquent and other neocortical areas
Jobst BC, Kapur R, Barkley GL, Bazil CW, Berg MJ, Bergey GK, Boggs JG, Cash SS, Cole AJ, Duchowny MS, Duckrow RB, Edwards JC, Eisenschenk S, Fessler AJ, Fountain NB, Geller EB, Goldman AM, Goodman RR, Gross RE, Gwinn RP, Heck C, Herekar AA, Hirsch LJ, King‐Stephens D, Labar DR, Marsh WR, Meador KJ, Miller I, Mizrahi EM, Murro AM, Nair DR, Noe KH, Olejniczak PW, Park YD, Rutecki P, Salanova V, Sheth RD, Skidmore C, Smith MC, Spencer DC, Srinivasan S, Tatum W, Van Ness P, Vossler DG, Wharen RE, Worrell GA, Yoshor D, Zimmerman RS, Skarpaas TL, Morrell MJ. Brain‐responsive neurostimulation in patients with medically intractable seizures arising from eloquent and other neocortical areas. Epilepsia 2017, 58: 1005-1014. PMID: 28387951, DOI: 10.1111/epi.13739.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBrain MappingCerebral CortexDeep Brain StimulationDrug Resistant EpilepsyElectric Stimulation TherapyElectrodes, ImplantedElectroencephalographyEpilepsies, PartialEpilepsy, Complex PartialEpilepsy, Partial, MotorEpilepsy, Tonic-ClonicFeasibility StudiesFemaleFollow-Up StudiesHumansMaleMiddle AgedNeocortexYoung AdultConceptsSeizure-free periodSeizure reductionNeocortical onsetSeizure onsetNeocortical originIntractable partial-onset seizuresMedian percent seizure reductionBrain-responsive neurostimulationChronic neurologic deficitsPercent seizure reductionPrior epilepsy surgeryPartial-onset seizuresPercent of patientsProspective clinical trialsNormal MRI findingsVagus nerve stimulationEffective treatment optionEloquent cortical areasRate of infectionMagnetic resonance imagingPreimplantation baselineMRI lesionsAdverse eventsNeurologic deficitsPerioperative hemorrhage
2016
Elevated basal glutamate and unchanged glutamine and GABA in refractory epilepsy: Microdialysis study of 79 patients at the yale epilepsy surgery program
Çavuş I, Romanyshyn JC, Kennard JT, Farooque P, Williamson A, Eid T, Spencer SS, Duckrow R, Dziura J, Spencer DD. Elevated basal glutamate and unchanged glutamine and GABA in refractory epilepsy: Microdialysis study of 79 patients at the yale epilepsy surgery program. Annals Of Neurology 2016, 80: 35-45. PMID: 27129611, DOI: 10.1002/ana.24673.Peer-Reviewed Original ResearchConceptsGABA levelsEpilepsy patientsΓ-aminobutyric acid (GABA) neurotransmissionGlutamine levelsGABAergic antiepileptic drugsEpilepsy surgery programRefractory epilepsy patientsCommon pathological featureAberrant glutamateAnn NeurolNonepileptogenic cortexSeizure-onset sitesRefractory epilepsyBasal glutamateAntiepileptic drugsCortical lesionsMicrodialysis studyPatient groupInterictal levelsPathological featuresDifferent etiologiesNeocortical epilepsyGlutamate levelsSeizure generationElectroencephalogram evaluation
2010
Background intracranial EEG spectral changes with anti-epileptic drug taper
Zaveri HP, Pincus SM, Goncharova II, Novotny EJ, Duckrow RB, Spencer DD, Blumenfeld H, Spencer SS. Background intracranial EEG spectral changes with anti-epileptic drug taper. Clinical Neurophysiology 2010, 121: 311-317. PMID: 20075002, DOI: 10.1016/j.clinph.2009.11.081.Peer-Reviewed Original Research
2009
Spatial distribution of intracranially recorded spikes in medial and lateral temporal epilepsies
Goncharova II, Zaveri HP, Duckrow RB, Novotny EJ, Spencer SS. Spatial distribution of intracranially recorded spikes in medial and lateral temporal epilepsies. Epilepsia 2009, 50: 2575-2585. PMID: 19674048, DOI: 10.1111/j.1528-1167.2009.02258.x.Peer-Reviewed Original ResearchConceptsMedial temporal structuresInterictal spikesLT patientsCortical areasNeocortical seizure onsetsSleep-related increaseSpike rateLateral temporal epilepsyExtratemporal areasTemporal epilepsySeizure onsetIntracranial monitoringLT groupMT groupPatientsFrontal spikesSeizuresGreater numberSleepGroupTemporal structureEpilepsySpikesLocalization-related epilepsy exhibits significant connectivity away from the seizure-onset area
Zaveri HP, Pincus SM, Goncharova II, Duckrow RB, Spencer DD, Spencer SS. Localization-related epilepsy exhibits significant connectivity away from the seizure-onset area. Neuroreport 2009, 20: 891-895. PMID: 19424095, DOI: 10.1097/wnr.0b013e32832c78e0.Peer-Reviewed Original ResearchConceptsSeizure onset areaLocalization-related epilepsyControl of seizuresDiscrete cortical areasStandard clinical proceduresBeta frequency bandsUnselected patientsComplete resectionEpilepsy surgeryCortical areasFunctional connectivitySeizuresClinical proceduresEpilepsyIntracranial electroencephalogramSignificant connectivityResectionPatientsSurgery
2008
Temporal distributions of seizure occurrence from various epileptogenic regions
Durazzo TS, Spencer SS, Duckrow RB, Novotny EJ, Spencer DD, Zaveri HP. Temporal distributions of seizure occurrence from various epileptogenic regions. Neurology 2008, 70: 1265-1271. PMID: 18391158, DOI: 10.1212/01.wnl.0000308938.84918.3f.Peer-Reviewed Original ResearchConceptsMesial temporal lobeSeizure occurrencePartial epilepsyTemporal lobeBrain regionsParietal seizuresSeizure distributionNeocortical temporal lobeParietal lobe seizuresTemporal lobe seizuresFrontal lobe seizuresConsecutive adult subjectsCortical brain regionsCircadian rhythmNeocortical temporalSurgical resectionTemporal seizuresIntracranial EEG recordingsEpileptogenic regionSeizuresAdult subjectsEpilepsyEndogenous circadian rhythmLobeEEG recordings
2007
Daily Variation in an Intracranial EEG Feature in Humans Detected by a Responsive Neurostimulator System
Duckrow RB, Tcheng TK. Daily Variation in an Intracranial EEG Feature in Humans Detected by a Responsive Neurostimulator System. Epilepsia 2007, 48: 1614-1620. PMID: 17442001, DOI: 10.1111/j.1528-1167.2007.01091.x.Peer-Reviewed Original Research
1991
Regional Cerebral Blood Flow during Spreading Cortical Depression in Conscious Rats
Duckrow R. Regional Cerebral Blood Flow during Spreading Cortical Depression in Conscious Rats. Cerebrovascular And Brain Metabolism Reviews 1991, 11: 150-154. PMID: 1983999, DOI: 10.1038/jcbfm.1991.18.Peer-Reviewed Original ResearchConceptsConscious ratsCortical depressionCBF changesRegional CBFRegional cerebral blood flowCerebral cortex contralateralConscious restrained ratsCerebral blood flowEarly transient increaseDirect current stimulationLateral frontal cortexRelative hyperperfusionCortex contralateralVascular responsesFrontal cortexRestrained ratsBlood flowCerebral hemispheresRatsCurrent stimulationTransient increaseBrain dissectionEEG activityCBFHyperperfusion
1981
Disparate recovery of resting and stimulated oxidative metabolism following transient ischemia.
Duckrow RB, LaManna JS, Rosenthal M. Disparate recovery of resting and stimulated oxidative metabolism following transient ischemia. Stroke 1981, 12: 677-686. PMID: 6272454, DOI: 10.1161/01.str.12.5.677.Peer-Reviewed Original ResearchConceptsMinutes of reperfusionTransient ischemiaMetabolic dysfunctionElectrocortical activityHours of reperfusionTransient cerebral ischemiaCarotid artery ligationOxidative responseLocal blood volumeOxidative metabolic functionCerebral ischemiaIschemic intervalArtery ligationRat brainBlood volumeElectrical stimulationCerebral surfaceReperfusionIschemiaOxidative metabolismMitochondrial redox stateDysfunctionEventual recoveryMetabolic functionsDisparate recoveryCerebral compensation for chronic noradrenergic denervation induced by locus ceruleus lesion: recovery of receptor binding, isoproterenol- induced adenylate cyclase activity, and oxidative metabolism
Harik SI, Duckrow RB, LaManna JC, Rosenthal M, Sharma VK, Banerjee SP. Cerebral compensation for chronic noradrenergic denervation induced by locus ceruleus lesion: recovery of receptor binding, isoproterenol- induced adenylate cyclase activity, and oxidative metabolism. Journal Of Neuroscience 1981, 1: 641-649. PMID: 7346572, PMCID: PMC6564177, DOI: 10.1523/jneurosci.01-06-00641.1981.Peer-Reviewed Original ResearchConceptsLocus ceruleus lesionNoradrenergic denervationCerebral cortexReceptor bindingNoradrenergic receptor bindingOxidative metabolismRat cerebral cortexDirect cortical stimulationVivo oxidative metabolismBlood volume shiftsCyclic AMP generationAdenylate cyclase activityCerebral compensationNoradrenaline depletionLocus ceruleusUnilateral injectionCortical stimulationCerebral noradrenalineLong-term effectsAMP generationMonophosphate generationLesionsDenervationCyclase activityWeeks