2022
Comparing Serum Matrix Metalloproteinase-7 in Parenteral Nutrition-Associated Liver Disease and Biliary Atresia
Salvi PS, Fawaz R, Cowles RA. Comparing Serum Matrix Metalloproteinase-7 in Parenteral Nutrition-Associated Liver Disease and Biliary Atresia. The Journal Of Pediatrics 2022, 249: 97-100. PMID: 35714967, DOI: 10.1016/j.jpeds.2022.06.014.Peer-Reviewed Original ResearchConceptsBiliary atresiaLiver diseaseParenteral nutrition-associated liver diseaseParenteral Nutrition–Associated Liver DiseaseMetalloproteinase-7Matrix metalloproteinase 7 levelsSerum matrix metalloproteinase-7Cross-sectional studyMatrix metalloproteinase-7Parenteral nutritionInvasive testingAtresiaInfantsDiseaseJaundice
2021
Reducing Underdiagnosis of Hirschsprung-Associated Enterocolitis: A Novel Scoring System
Lewit RA, Veras LV, Cowles RA, Fowler K, King S, Lapidus-Krol E, Langer JC, Park CJ, Youssef F, Vavilov S, Gosain A. Reducing Underdiagnosis of Hirschsprung-Associated Enterocolitis: A Novel Scoring System. Journal Of Surgical Research 2021, 261: 253-260. PMID: 33460971, PMCID: PMC8166452, DOI: 10.1016/j.jss.2020.12.030.Peer-Reviewed Original ResearchConceptsHirschsprung-associated enterocolitisNew scoring systemSensitivity/specificityScoring systemHirschsprung's diseaseMultivariate analysisPercent of patientsReceipt of treatmentStepwise multivariate analysisProspective data collectionNovel scoring systemHAEC episodesRectal irrigationBowel restSignificant underdiagnosisRadiographic findingsPatient cohortColonic diseaseMore episodesUnivariate analysisHigh riskDiagnostic cutoffHead comparisonClinical settingLogistic regression
2018
Surgical modifications of the Kasai hepatoportoenterostomy minimize invasiveness without compromising short- and medium-term outcomes
Park CJ, Armenia SJ, Keung CH, Compton JT, Cowles RA. Surgical modifications of the Kasai hepatoportoenterostomy minimize invasiveness without compromising short- and medium-term outcomes. Journal Of Pediatric Surgery 2018, 54: 537-542. PMID: 30041859, DOI: 10.1016/j.jpedsurg.2018.06.028.Peer-Reviewed Original ResearchConceptsKasai hepatoportoenterostomyBiliary atresiaLiver transplantLiver transplant proceduresNative liver survivalEffective surgical therapyMedium-term outcomesYears of ageLiver survivalLiver dysfunctionOverall survivalSurgical therapyLiver failureBile stasisMedian timeProgressive fibrosisBile drainageTransplant proceduresMean ageBiliary treeSingle institutionPatient outcomesPortal plateSurgical modificationsAbdominal cavity