2022
Index Admission Cholecystectomy and Recurrence of Pediatric Gallstone Pancreatitis: Multicenter Cohort Analysis.
Muñoz Abraham AS, Osei H, Bajinting A, Cowles RA, Greenspon J, Hosfield BD, Keller MS, Landman MP, Owens H, Shaughnessy MP, St Peter SD, Sujka J, Vogel AM, Villalona GA. Index Admission Cholecystectomy and Recurrence of Pediatric Gallstone Pancreatitis: Multicenter Cohort Analysis. Journal Of The American College Of Surgeons 2022, 234: 352-358. PMID: 35213498, DOI: 10.1097/xcs.0000000000000062.Peer-Reviewed Original ResearchConceptsGallstone pancreatitisEarly cholecystectomyIndex admissionRecurrent pancreatitisRecurrence rateMean body mass indexIndex admission cholecystectomyMean age 13.5Multicenter cohort analysisTiming of cholecystectomyBody mass indexBiliary complicationsInterval cholecystectomyIndex dischargeCholecystectomy ratesGroup patientsMost patientsLaboratory characteristicsMild pancreatitisPediatric patientsRetrospective reviewMass indexCholecystectomyCohort analysisPancreatitis
2021
Laparoscopy is increasingly used for pediatric inguinal hernia repair
Shaughnessy MP, Maassel NL, Yung N, Solomon DG, Cowles RA. Laparoscopy is increasingly used for pediatric inguinal hernia repair. Journal Of Pediatric Surgery 2021, 56: 2016-2021. PMID: 33549307, DOI: 10.1016/j.jpedsurg.2021.01.032.Peer-Reviewed Original ResearchConceptsLaparoscopic inguinal hernia repairInguinal hernia repairHernia repairLaparoscopic repairCHA HospitalProcedure typePediatric Health Information SystemPediatric inguinal hernia repairStudy periodDefinitive prospective studiesLong-term outcomesTotal hospital costsUse of laparoscopyTen-year study periodIHR groupLaparoscopic groupYounger patientsProspective studyHospital costsOperative approachSurgeon preferencePediatric surgeonsHealth information systemsAbstractTextLaparoscopyReducing Underdiagnosis of Hirschsprung-Associated Enterocolitis: A Novel Scoring System
Lewit RA, Veras LV, Cowles RA, Fowler K, King S, Lapidus-Krol E, Langer JC, Park CJ, Youssef F, Vavilov S, Gosain A. Reducing Underdiagnosis of Hirschsprung-Associated Enterocolitis: A Novel Scoring System. Journal Of Surgical Research 2021, 261: 253-260. PMID: 33460971, PMCID: PMC8166452, DOI: 10.1016/j.jss.2020.12.030.Peer-Reviewed Original ResearchConceptsHirschsprung-associated enterocolitisNew scoring systemSensitivity/specificityScoring systemHirschsprung's diseaseMultivariate analysisPercent of patientsReceipt of treatmentStepwise multivariate analysisProspective data collectionNovel scoring systemHAEC episodesRectal irrigationBowel restSignificant underdiagnosisRadiographic findingsPatient cohortColonic diseaseMore episodesUnivariate analysisHigh riskDiagnostic cutoffHead comparisonClinical settingLogistic regression
2020
Mucosal characteristics vary across developmental stages in the small intestine of C57BL/6J mice
Park CJ, Shaughnessy MP, Cowles RA. Mucosal characteristics vary across developmental stages in the small intestine of C57BL/6J mice. Life Sciences 2020, 260: 118428. PMID: 32931798, DOI: 10.1016/j.lfs.2020.118428.Peer-Reviewed Original Research
2019
Orally Dosed Citalopram Stimulates Small Intestinal Mucosal Growth
Zhang L, Greig CJ, Cowles RA. Orally Dosed Citalopram Stimulates Small Intestinal Mucosal Growth. Journal Of Surgical Research 2019, 236: 326-331. PMID: 30694773, DOI: 10.1016/j.jss.2018.11.033.Peer-Reviewed Original ResearchConceptsMucosal surface areaSelective serotonin reuptake inhibitorsSerotonin reuptake inhibitorsIntestinal mucosal growthVillus heightVillus widthD citalopramReuptake inhibitorsMucosal growthCrypt depthCrypt widthSmall intestinal mucosal growthShort bowel syndromeT-testSerious intestinal disordersStudent's t-testOral agentsBowel syndromeOral therapyEnteral administrationC57BL/6 miceIleal segmentIntestinal disordersDay 21Day 7
2018
The 5-HT4 Receptor Agonist Prucalopride Stimulates Mucosal Growth and Enhances Carbohydrate Absorption in the Ileum of the Mouse
Park CJ, Armenia SJ, Zhang L, Cowles RA. The 5-HT4 Receptor Agonist Prucalopride Stimulates Mucosal Growth and Enhances Carbohydrate Absorption in the Ileum of the Mouse. Journal Of Gastrointestinal Surgery 2018, 23: 1198-1205. PMID: 30109470, DOI: 10.1007/s11605-018-3907-6.Peer-Reviewed Original ResearchConceptsDistal small bowelD-xylose absorptionCrypt cell proliferationSmall intestineMurine small intestineSmall bowelMucosal growthSpecific agonistCrypt depthGlucose absorptionIntestinal mucosal surface areaAdult wild-type miceMucosal growth factorsPotentiation of serotoninReceptor agonist prucaloprideDistal small intestineCell proliferationIntestinal mucosal growthWild-type miceReceptor-specific agonistsMiddle small intestineMucosal surface areaEnteric serotoninOral gavageCarbohydrate absorptionSurgical modifications of the Kasai hepatoportoenterostomy minimize invasiveness without compromising short- and medium-term outcomes
Park CJ, Armenia SJ, Keung CH, Compton JT, Cowles RA. Surgical modifications of the Kasai hepatoportoenterostomy minimize invasiveness without compromising short- and medium-term outcomes. Journal Of Pediatric Surgery 2018, 54: 537-542. PMID: 30041859, DOI: 10.1016/j.jpedsurg.2018.06.028.Peer-Reviewed Original ResearchConceptsKasai hepatoportoenterostomyBiliary atresiaLiver transplantLiver transplant proceduresNative liver survivalEffective surgical therapyMedium-term outcomesYears of ageLiver survivalLiver dysfunctionOverall survivalSurgical therapyLiver failureBile stasisMedian timeProgressive fibrosisBile drainageTransplant proceduresMean ageBiliary treeSingle institutionPatient outcomesPortal plateSurgical modificationsAbdominal cavity
2016
Enhanced serotonin signaling stimulates ordered intestinal mucosal growth
Tackett JJ, Gandotra N, Bamdad MC, Muise ED, Cowles RA. Enhanced serotonin signaling stimulates ordered intestinal mucosal growth. Journal Of Surgical Research 2016, 208: 198-203. PMID: 27993209, DOI: 10.1016/j.jss.2016.09.036.Peer-Reviewed Original Research
2001
Doctor-patient communication in surgery: attitudes and expectations of general surgery patients about the involvement and education of surgical residents1 1No competing interests declared.
Cowles R, Moyer C, Sonnad S, Simeone D, Knol J, Eckhauser F, Mulholland M, Colletti L. Doctor-patient communication in surgery: attitudes and expectations of general surgery patients about the involvement and education of surgical residents1 1No competing interests declared. Journal Of The American College Of Surgeons 2001, 193: 73-80. PMID: 11442257, DOI: 10.1016/s1072-7515(01)00936-x.Peer-Reviewed Original ResearchConceptsSurgical resident educationPatients' perceptionsGastrointestinal surgery serviceGeneral surgery patientsMajority of patientsAttitudes of patientsInpatient hospital stayResident educationAcademic medical centerDoctor-patient communicationHospital staySurgery patientsSurgery serviceTeaching hospitalMedical CenterSurgical servicesPatients' answersSurgical settingPatientsInstitution residentsCareSurgical residentsPatient orientationExtra attentionImpact of residents
2000
Efficacy of the laparoscopic approach for anterior lumbar spinal fusion
Cowles R, Taheri P, Sweeney J, Graziano G. Efficacy of the laparoscopic approach for anterior lumbar spinal fusion. Surgery 2000, 128: 589-596. PMID: 11015092, DOI: 10.1067/msy.2000.108055.Peer-Reviewed Original ResearchConceptsAnterior lumbar spinal fusionLumbar spinal fusionLess blood lossLaparoscopic proceduresSpinal fusionBlood lossOpen procedureShorter operating room timeShorter postoperative ileusCharts of patientsImmediate postoperative outcomesImmediate postoperative resultsOperating room timePostoperative ileusPostoperative coursePostoperative outcomesLaparoscopic approachOperative timePostoperative resultsPatientsRoom timeLearning curveIleusLaparoscopicEpidermoid cyst of the spleen
Cowles R, Yahanda A. Epidermoid cyst of the spleen. The American Journal Of Surgery 2000, 180: 227. PMID: 11084135, DOI: 10.1016/s0002-9610(00)00446-3.Peer-Reviewed Case Reports and Technical NotesLaparoscopic biopsy of abdominal retroperitoneal lymphadenopathy for the diagnosis of lymphoma11No competing interests declared.
Cowles R, Yahanda A. Laparoscopic biopsy of abdominal retroperitoneal lymphadenopathy for the diagnosis of lymphoma11No competing interests declared. Journal Of The American College Of Surgeons 2000, 191: 108-113. PMID: 10898191, DOI: 10.1016/s1072-7515(00)00279-9.Peer-Reviewed Original Research
1999
Useful techniques for the resection of foot melanomas
Cowles R, Johnson T, Chang A. Useful techniques for the resection of foot melanomas. Journal Of Surgical Oncology 1999, 70: 255-259. PMID: 10219023, DOI: 10.1002/(sici)1096-9098(199904)70:4<255::aid-jso11>3.0.co;2-b.Peer-Reviewed Original Research