2019
Orally Dosed Citalopram Stimulates Small Intestinal Mucosal Growth
Zhang L, Greig CJ, Cowles RA. Orally Dosed Citalopram Stimulates Small Intestinal Mucosal Growth. Journal Of Surgical Research 2019, 236: 326-331. PMID: 30694773, DOI: 10.1016/j.jss.2018.11.033.Peer-Reviewed Original ResearchConceptsMucosal surface areaSelective serotonin reuptake inhibitorsSerotonin reuptake inhibitorsIntestinal mucosal growthVillus heightVillus widthD citalopramReuptake inhibitorsMucosal growthCrypt depthCrypt widthSmall intestinal mucosal growthShort bowel syndromeT-testSerious intestinal disordersStudent's t-testOral agentsBowel syndromeOral therapyEnteral administrationC57BL/6 miceIleal segmentIntestinal disordersDay 21Day 7
2016
Enhanced serotonin signaling increases intestinal neuroplasticity
Greig CJ, Gandotra N, Tackett JJ, Bamdad MC, Cowles RA. Enhanced serotonin signaling increases intestinal neuroplasticity. Journal Of Surgical Research 2016, 206: 151-158. PMID: 27916355, DOI: 10.1016/j.jss.2016.07.021.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsIntestinal mucosal growthSERT knockoutMucosal growthEnterocyte proliferationEnteric nervous systemSerotonin reuptake inhibitorsMassive bowel resectionSerotonin reuptake transporterAge-matched WTGAP-43 expressionWild-type miceSynthesis inhibitionMarkers of neuroplasticityImportant regulatorReversal of effectsEpithelial cell compartmentWestern blot analysisBowel resectionReuptake inhibitorsWT miceReuptake transporterMucosal homeostasisIntestinal segmentsCrypt depth