The 5-HT4 Receptor Agonist Prucalopride Stimulates Mucosal Growth and Enhances Carbohydrate Absorption in the Ileum of the Mouse
Park CJ, Armenia SJ, Zhang L, Cowles RA. The 5-HT4 Receptor Agonist Prucalopride Stimulates Mucosal Growth and Enhances Carbohydrate Absorption in the Ileum of the Mouse. Journal Of Gastrointestinal Surgery 2018, 23: 1198-1205. PMID: 30109470, DOI: 10.1007/s11605-018-3907-6.Peer-Reviewed Original ResearchConceptsDistal small bowelD-xylose absorptionCrypt cell proliferationSmall intestineMurine small intestineSmall bowelMucosal growthSpecific agonistCrypt depthGlucose absorptionIntestinal mucosal surface areaAdult wild-type miceMucosal growth factorsPotentiation of serotoninReceptor agonist prucaloprideDistal small intestineCell proliferationIntestinal mucosal growthWild-type miceReceptor-specific agonistsMiddle small intestineMucosal surface areaEnteric serotoninOral gavageCarbohydrate absorption