2023
Antibiotic-induced microbial depletion enhances murine small intestinal epithelial growth in a serotonin-dependent manner
Salvi P, Shaughnessy M, Sumigray K, Cowles R. Antibiotic-induced microbial depletion enhances murine small intestinal epithelial growth in a serotonin-dependent manner. AJP Gastrointestinal And Liver Physiology 2023, 325: g80-g91. PMID: 37158470, DOI: 10.1152/ajpgi.00113.2022.Peer-Reviewed Original ResearchConceptsSerotonin activitySERT protein expressionSerotonin potentiationEpithelial proliferationSerotonin transporterEndogenous serotoninVillus heightMicrobial depletionIntestinal epithelial growthProtein expressionEpithelial growthSerotonin-dependent mechanismIntestinal villus heightSmall intestine resultsIntestinal surface areaSmall intestinal villiSmall intestinal cryptsIntestinal pathologyPara-chlorophenylalanineISC numbersSerotonin synthesisIntestinal homeostasisEpithelial expressionMouse modelAnimal models
2018
Mucosal homeostasis is altered in the ileum of gnotobiotic mice
Greig CJ, Alper A, Goodman AL, Cowles RA. Mucosal homeostasis is altered in the ileum of gnotobiotic mice. Journal Of Surgical Research 2018, 231: 331-337. PMID: 30278949, DOI: 10.1016/j.jss.2018.05.055.Peer-Reviewed Original ResearchConceptsGnotobiotic miceMucosal homeostasisGastrointestinal tractCrypt depthVillus heightDistal ileal segmentConventional floraFuture therapeutic strategiesGnotobiotic mouse modelMarkers of proliferationIleal segmentMucosal restorationAkkermansia muciniphilaMouse modelTherapeutic strategiesAdult miceCF miceDisease pathogenesisHistologic sectionsMiceEscherichia coli MG1655IleumNormal physiologyGnotobiotic groupFurther studies
2017
Improved capacity to evaluate changes in intestinal mucosal surface area using mathematical modeling
Greig CJ, Cowles RA. Improved capacity to evaluate changes in intestinal mucosal surface area using mathematical modeling. Microscopy Research And Technique 2017, 80: 793-798. PMID: 28295852, DOI: 10.1002/jemt.22866.Peer-Reviewed Original ResearchConceptsMucosal surface areaIntestinal mucosal surface areaVillus heightCrypt widthMucosal growthSelective serotonin reuptakeIntestinal mucosal growthEffects of interventionsFunctional intestinal mucosaEnhanced serotoninBowel diameterSerotonin reuptakeIntestinal mucosaMouse modelIleal sectionsTransporter moleculesMorphometric measuresComprehensive assessmentSSRIsMorphometric parametersMucosaSerotoninStandard measuresTherapyReuptake