Potentiated serotonin signaling in serotonin re‐uptake transporter knockout mice increases enterocyte mass and small intestinal absorptive function
Greig CJ, Zhang L, Cowles RA. Potentiated serotonin signaling in serotonin re‐uptake transporter knockout mice increases enterocyte mass and small intestinal absorptive function. Physiological Reports 2019, 7: e14278. PMID: 31724827, PMCID: PMC6854605, DOI: 10.14814/phy2.14278.Peer-Reviewed Original ResearchConceptsIntestinal absorptive functionEnterocyte massCrypt proliferation indexSmall intestineAbsorptive functionDistal bowelSmall bowelCrypt depthSERT knockoutVillus heightProliferative parametersSmall intestinal absorptive functionPlasma citrulline levelsCrypt cell proliferationPeptide absorptionSignificant increaseMucosal surface areaAttractive therapeutic targetFunctional intestinal mucosaWT miceCitrulline levelsPlasma citrullineSerotonin systemIntestinal mucosaLuminal instillationSerum Citrulline Levels Exhibit Circadian Variation and Fluctuations in Relation to Food Intake in Mice
Park CJ, Shaughnessy MP, Armenia SJ, Cowles RA. Serum Citrulline Levels Exhibit Circadian Variation and Fluctuations in Relation to Food Intake in Mice. Gastroenterology Research 2019, 12: 88-92. PMID: 31019618, PMCID: PMC6469904, DOI: 10.14740/gr1146.Peer-Reviewed Original ResearchSerum citrulline levelsCitrulline levelsFood intakeSmall intestineCircadian variationFunctional intestinal massSmall bowel massPlasma citrulline levelsUse Committee guidelinesBowel massEnteral autonomySerum citrullineIntestinal failureEnterocyte massC57BL/6 micePrognostic valueFed micePlasma citrullineBlood drawIntestinal massNonessential amino acidsInstitutional Animal CareSimple biomarkerAnimal modelsVillus height