RET Activation and Clinicopathologic Features in Poorly Differentiated Thyroid Tumors
Santoro M, Papotti M, Chiappetta G, Garcia-Rostan G, Volante M, Johnson C, Camp RL, Pentimalli F, Monaco C, Herrero A, Carcangiu ML, Fusco A, Tallini G. RET Activation and Clinicopathologic Features in Poorly Differentiated Thyroid Tumors. The Journal Of Clinical Endocrinology & Metabolism 2002, 87: 370-379. PMID: 11788678, DOI: 10.1210/jcem.87.1.8174.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overCarcinoma, PapillaryCell DifferentiationDrosophila ProteinsFemaleGene RearrangementHumansImmunohistochemistryLymphatic MetastasisMaleMiddle AgedOncogene Proteins, FusionPrognosisProtein-Tyrosine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-retReceptor Protein-Tyrosine KinasesReverse Transcriptase Polymerase Chain ReactionSurvival AnalysisThyroid NeoplasmsConceptsRET/PTC rearrangementsRET/PTCClinicopathologic parametersRET activationInsular growth patternRelevant clinicopathologic parametersClinical characteristicsClinicopathologic featuresDistant metastasisSignificant morbidityDifferentiated tumorsHistologic evidenceMale sexAnaplastic carcinomaPatient outcomesPoor survivalEpithelial neoplasmsPapillary carcinomaLow prevalenceOncocytic featuresThyroid tumorsSurvival analysisThyroid glandMorphologic featuresSame tumor