AQUA analysis of thymidylate synthase reveals localization to be a key prognostic biomarker in 2 large cohorts of colorectal carcinoma.
Gustavson MD, Molinaro AM, Tedeschi G, Camp RL, Rimm DL. AQUA analysis of thymidylate synthase reveals localization to be a key prognostic biomarker in 2 large cohorts of colorectal carcinoma. Archives Of Pathology & Laboratory Medicine 2008, 132: 1746-52. PMID: 18976010, DOI: 10.5858/132.11.1746.Peer-Reviewed Original ResearchConceptsThymidylate synthase expressionSynthase expressionColorectal carcinomaSignificant associationDisease-specific survivalColon cancer outcomesColon cancer survivalKey prognostic biomarkersRetrospective cohortNodal statusPrognostic valueColorectal cancerCancer outcomesCancer survivalPathologic classificationPrognostic biomarkerLarge cohortSecond cohortAQUA scoreCytoplasmic expressionNuclear expressionCohortHigh nuclearCytoplasmic ratioFirst cohort