2007
Analysis of p53 protein expression levels on ovarian cancer tissue microarray using automated quantitative analysis elucidates prognostic patient subsets
Psyrri A, Kountourakis P, Yu Z, Papadimitriou C, Markakis S, Camp R, Economopoulos T, Dimopoulos M. Analysis of p53 protein expression levels on ovarian cancer tissue microarray using automated quantitative analysis elucidates prognostic patient subsets. Annals Of Oncology 2007, 18: 709-715. PMID: 17220511, DOI: 10.1093/annonc/mdl479.Peer-Reviewed Original ResearchConceptsDisease-free survivalOverall survivalP53 protein levelsP53 expression levelsPrognostic valueOvarian cancerBetter outcomesProtein levelsAdvanced stage ovarian cancerExpression levelsP53 protein expression levelsOvarian cancer tissue microarrayStage ovarian cancerOvarian cancer prognosisP53 levelsCancer tissue microarrayValuable prognostic markerP53 protein expressionSignificant predictor variablesProtein expression levelsObstetrics stageFIGO stagePatient subsetsMultivariable analysisPrognostic marker
2006
Automated quantitative analysis of DCC tumor suppressor protein in ovarian cancer tissue microarray shows association with β-catenin levels and outcome in patients with epithelial ovarian cancer
Bamias A, Yu Z, Weinberger P, Markakis S, Kowalski D, Camp R, Rimm D, Dimopoulos M, Psyrri A. Automated quantitative analysis of DCC tumor suppressor protein in ovarian cancer tissue microarray shows association with β-catenin levels and outcome in patients with epithelial ovarian cancer. Annals Of Oncology 2006, 17: 1797-1802. PMID: 16971669, DOI: 10.1093/annonc/mdl310.Peer-Reviewed Original ResearchConceptsEpithelial ovarian cancerOvarian cancerPatient outcomesDCC expressionPlatinum-paclitaxel combination chemotherapyProgression-free survival ratesAdvanced stage ovarian cancerOvarian cancer tissue microarrayAssociation of DCCCancer tissue microarrayPoor patient outcomesBeta-catenin levelsDCC tumor suppressor geneColorectal cancer (DCC) proteinMedian followSurgical debulkingCombination chemotherapyPrognostic significanceEntire cohortPreclinical dataClinicopathological parametersAntitumor functionΒ-catenin levelsTissue microarraySufficient tissue