2009
Defining Molecular Phenotypes of Human Papillomavirus–Associated Oropharyngeal Squamous Cell Carcinoma
Weinberger PM, Yu Z, Kountourakis P, Sasaki C, Haffty BG, Kowalski D, Merkley MA, Rimm DL, Camp RL, Psyrri A. Defining Molecular Phenotypes of Human Papillomavirus–Associated Oropharyngeal Squamous Cell Carcinoma. Otolaryngology 2009, 141: 382-389. PMID: 19716018, DOI: 10.1016/j.otohns.2009.04.014.Peer-Reviewed Original ResearchConceptsOropharyngeal squamous cell carcinomaSquamous cell carcinomaCell carcinomaHuman Papillomavirus–Associated Oropharyngeal Squamous Cell CarcinomaP16 expressionTertiary care academic medical centerDNA presenceHPV DNA presenceVascular endothelial growth factorCross-sectional studyAcademic medical centerEndothelial growth factorEpidermal growth factor receptorMolecular phenotypesGrowth factor receptorOSCC specimensCervical cancerUnsupervised hierarchical clusteringMedical CenterDifferent molecular phenotypesTumorsGrowth factorExpression patternsFactor receptorProtein expression
2008
Molecular Classification of HPV‐Associated Head Neck Cancer
Weinberger P, Yu Z, Kountourakis P, Sasaki C, Kowalski D, Rimm D, Camp R, Amanda P. Molecular Classification of HPV‐Associated Head Neck Cancer. Otolaryngology 2008, 139: p91-p91. DOI: 10.1016/j.otohns.2008.05.497.Peer-Reviewed Original ResearchHPV DNA presenceClass II tumorsII tumorsClass IP16 expressionDNA presenceNeck squamous cell carcinomaHPV-specific therapiesHuman papillomavirus presenceSquamous cell carcinomaHead neck cancerP16 expression statusDistinct molecular phenotypesPatient selectionCell carcinomaNeck cancerExpression statusTumor progressionTumorsClass IIIMethods ParaffinClass IIMolecular classificationSpearman correlationDistinct subgroups