Utility of molecular genetic signatures in the delineation of gastric neoplasia
Kidd M, Modlin IM, Mane SM, Camp RL, Eick GN, Latich I, Zikusoka MN. Utility of molecular genetic signatures in the delineation of gastric neoplasia. Cancer 2006, 106: 1480-1488. PMID: 16502410, DOI: 10.1002/cncr.21758.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdenocarcinomaAdultAgedAntigens, NeoplasmCarcinoid TumorChromogranin AChromograninsDiagnosis, DifferentialFemaleGene Expression ProfilingGenetic MarkersHistone DeacetylasesHumansImmunohistochemistryMaleMiddle AgedNeoplasm InvasivenessOligonucleotide Array Sequence AnalysisPhenotypeRepressor ProteinsReverse Transcriptase Polymerase Chain ReactionStomach NeoplasmsTrans-ActivatorsConceptsType III/IVGastric carcinoidsMAGE-D2Gastric neoplasiaMolecular genetic signaturesType I/IIGenetic signaturesTumor invasionSimilar expression patternsCgA protein levelsProtein expression levelsII tumorsStromal tumorsClinical behaviorGastric adenocarcinomaGastric neoplasmsMTA1 levelsNormal mucosaImmunohistochemical analysisMolecular basisExpression patternsGene expressionTumorsGene signatureBiological rationaleQ RT-PCR Detection of Chromogranin A
Kidd M, Modlin IM, Mane SM, Camp RL, Shapiro MD. Q RT-PCR Detection of Chromogranin A. Annals Of Surgery 2006, 243: 273-280. PMID: 16432362, PMCID: PMC1448909, DOI: 10.1097/01.sla.0000197734.28551.0f.Peer-Reviewed Original ResearchConceptsGI carcinoidsGI adenocarcinomasQ-RT-PCRNormal mucosaLymph node metastasisNormal lymph nodesCgA gene expressionCgA protein levelsProtein expression levelsAppendiceal tumorsNormal LNsLiver metastasesLN metastasisLymph nodesNode metastasisAppendiceal carcinoidsNonmetastatic lesionsEpithelial tumorsCgA levelsTissue microarrayTherapeutic strategiesCarcinoidsNE cellsImmunohistochemical measurementsRT-PCR detection