Automated quantitative analysis of DCC tumor suppressor protein in ovarian cancer tissue microarray shows association with β-catenin levels and outcome in patients with epithelial ovarian cancer
Bamias A, Yu Z, Weinberger P, Markakis S, Kowalski D, Camp R, Rimm D, Dimopoulos M, Psyrri A. Automated quantitative analysis of DCC tumor suppressor protein in ovarian cancer tissue microarray shows association with β-catenin levels and outcome in patients with epithelial ovarian cancer. Annals Of Oncology 2006, 17: 1797-1802. PMID: 16971669, DOI: 10.1093/annonc/mdl310.Peer-Reviewed Original ResearchConceptsEpithelial ovarian cancerOvarian cancerPatient outcomesDCC expressionPlatinum-paclitaxel combination chemotherapyProgression-free survival ratesAdvanced stage ovarian cancerOvarian cancer tissue microarrayAssociation of DCCCancer tissue microarrayPoor patient outcomesBeta-catenin levelsDCC tumor suppressor geneColorectal cancer (DCC) proteinMedian followSurgical debulkingCombination chemotherapyPrognostic significanceEntire cohortPreclinical dataClinicopathological parametersAntitumor functionΒ-catenin levelsTissue microarraySufficient tissue