Quantitative analysis of breast cancer tissue microarrays shows that both high and normal levels of HER2 expression are associated with poor outcome.
Camp RL, Dolled-Filhart M, King BL, Rimm DL. Quantitative analysis of breast cancer tissue microarrays shows that both high and normal levels of HER2 expression are associated with poor outcome. Cancer Research 2003, 63: 1445-8. PMID: 12670887.Peer-Reviewed Original ResearchConceptsHER2 expressionLow-level HER2 expressionHER2/neu expressionHER2-overexpressing tumorsDisease-related survivalTissue microarray cohortNormal breast epitheliumBreast cancer tissuesMicroarray cohortPoor outcomeNeu expressionWorse outcomesBreast cancerImmunohistochemical stainsBreast epitheliumNormal epitheliumCancer tissuesBreast tumorsTumorsNormal levelsExpression levelsHER2AQUA analysisDetectable levelsLow group