Validation and Comparison of Pharmacogenetics-Based Warfarin Dosing Algorithms for Application of Pharmacogenetic Testing
Roper N, Storer B, Bona R, Fang M. Validation and Comparison of Pharmacogenetics-Based Warfarin Dosing Algorithms for Application of Pharmacogenetic Testing. Journal Of Molecular Diagnostics 2010, 12: 283-291. PMID: 20228265, PMCID: PMC2860463, DOI: 10.2353/jmoldx.2010.090110.Peer-Reviewed Original ResearchConceptsPharmacogenetics-based dosing algorithmDosing algorithmInternational Warfarin Pharmacogenetics ConsortiumPercentage of patientsNarrow therapeutic windowDiverse ethnic populationsMaintenance dosesProspective trialWarfarin dosesWarfarin dosingPrescribed drugsPharmacogenetic testingWarfarin metabolismIWPC algorithmClinical utilityDosing rangeTherapeutic windowWarfarinGenetic testingPatientsGenetic polymorphismsExternal validationEthnic populationsService populationCYP2C9