1990
Basolateral membrane Na(+)-independent Cl-/HCO3- exchange in the inner stripe of the rabbit outer medullary collecting tubule.
Hays SR, Alpern RJ. Basolateral membrane Na(+)-independent Cl-/HCO3- exchange in the inner stripe of the rabbit outer medullary collecting tubule. The Journal Of General Physiology 1990, 95: 347-367. PMID: 2307960, PMCID: PMC2216319, DOI: 10.1085/jgp.95.2.347.Peer-Reviewed Original ResearchConceptsInner stripePeritubular ClDistal nephron segmentsBasolateral membraneCell acidificationCell pHLuminal changesUrinary acidificationNephron segmentsPH-sensitive fluorescent dyeIndependent ClCell alkalinizationCO2/HCO3Peritubular pHVoltage clampTubulesTwo-thirdsRabbitsTotal replacementCell pH changes
1989
Basolateral membrane H-OH-HCO3 transport in the proximal tubule
Preisig P, Alpern R. Basolateral membrane H-OH-HCO3 transport in the proximal tubule. American Journal Of Physiology 1989, 256: f751-f765. PMID: 2541627, DOI: 10.1152/ajprenal.1989.256.5.f751.Peer-Reviewed Original ResearchConceptsProximal tubulesS3 proximal tubuleChronic respiratory acidosisChronic metabolic acidosisRabbit proximal tubuleChronic hyperfiltrationMetabolic acidosisNa-H antiporterRespiratory acidosisCl-HCO3 exchangerCl absorptionGreater transport capacityAlkalosisAcidosisTubulesTransporter activityMembrane mechanismsBasolateral membraneCotransporterHyperfiltrationRatsEpithelium
1988
Chronic metabolic acidosis causes an adaptation in the apical membrane Na/H antiporter and basolateral membrane Na(HCO3)3 symporter in the rat proximal convoluted tubule.
Preisig PA, Alpern RJ. Chronic metabolic acidosis causes an adaptation in the apical membrane Na/H antiporter and basolateral membrane Na(HCO3)3 symporter in the rat proximal convoluted tubule. Journal Of Clinical Investigation 1988, 82: 1445-1453. PMID: 2844858, PMCID: PMC442703, DOI: 10.1172/jci113750.Peer-Reviewed Original ResearchConceptsChronic metabolic acidosisNa/H antiporterMetabolic acidosisAcidotic animalsH antiporterVivo microperfused rat proximal tubuleDpHi/dtRat proximal tubuleBasolateral membraneTransporter activityDietary acidPeritubular capillariesProximal tubulesNa/HPH-sensitive fluorescent dyeAcidosisTubulesSubsequent studiesAnimalsCarboxy-fluoresceinAbsence of contactCells
1987
Basolateral membrane Cl/HCO3 exchange in the rat proximal convoluted tubule. Na-dependent and -independent modes.
Alpern RJ, Chambers M. Basolateral membrane Cl/HCO3 exchange in the rat proximal convoluted tubule. Na-dependent and -independent modes. The Journal Of General Physiology 1987, 89: 581-598. PMID: 2953859, PMCID: PMC2215917, DOI: 10.1085/jgp.89.4.581.Peer-Reviewed Original ResearchConceptsCl/HCO3 exchangeNa-free solutionHCO3- exchangePeritubular NaCell pHHCO3- transport mechanismsBasolateral membraneProximal tubulesCoupling of NaMammalian proximal tubuleMeq/Similar increaseAmbient ClExtracellular fluidTubulesNa dependenceCotransporterNa concentrationCl concentrationsCellsSimilar amountsApical membrane chloride/base exchange in the rat proximal convoluted tubule.
Alpern RJ. Apical membrane chloride/base exchange in the rat proximal convoluted tubule. Journal Of Clinical Investigation 1987, 79: 1026-1030. PMID: 3558814, PMCID: PMC424279, DOI: 10.1172/jci112914.Peer-Reviewed Original ResearchCarbonic Anhydrase Inhibitors
Preisig PA, Toto RD, Alpern RJ. Carbonic Anhydrase Inhibitors. Renal Physiology 1987, 10: 136-159. PMID: 3133728, DOI: 10.1159/000173126.Peer-Reviewed Original Research
1985
Mechanism of basolateral membrane H+/OH-/HCO-3 transport in the rat proximal convoluted tubule. A sodium-coupled electrogenic process.
Alpern RJ. Mechanism of basolateral membrane H+/OH-/HCO-3 transport in the rat proximal convoluted tubule. A sodium-coupled electrogenic process. The Journal Of General Physiology 1985, 86: 613-636. PMID: 2999293, PMCID: PMC2228817, DOI: 10.1085/jgp.86.5.613.Peer-Reviewed Original ResearchConceptsUnits/minPeritubular pHHigh extracellular potassium concentrationCell pHSodium concentrationPotassium concentrationExtracellular potassium concentrationBasolateral membranePeritubular potassium concentrationCell depolarizationMeq/Sodium removalCell acidificationTubulesPeritubular fluidTotal absenceSitCellsRatsMinSodiumActive and passive components of chloride transport in the rat proximal convoluted tubule.
Alpern RJ, Howlin KJ, Preisig PA. Active and passive components of chloride transport in the rat proximal convoluted tubule. Journal Of Clinical Investigation 1985, 76: 1360-1366. PMID: 4056034, PMCID: PMC424076, DOI: 10.1172/jci112111.Peer-Reviewed Original Research