1997
Pathogenesis of edema formation in the nephrotic syndrome.
Palmer BF, Alpern RJ. Pathogenesis of edema formation in the nephrotic syndrome. Kidney International Supplement 1997, 59: s21-7. PMID: 9185099.Peer-Reviewed Original ResearchConceptsPlasma oncotic pressureEdema formationNephrotic syndromeOncotic pressurePlasma volumeEffective circulatory volumeMost nephrotic patientsPrimary salt retentionPrimary sodium retentionMinority of patientsCapillary fluid filtrationAtrial natriuretic peptideDevelopment of edemaNeurohumoral markersIntrarenal mechanismsNatriuretic effectNephrotic patientsSodium retentionCirculatory volumeIntravascular volumeNatriuretic peptideEffector mechanismsUrinary lossTubular resistanceIntravascular space
1991
Regulation of proximal reabsorption by effective arterial blood volume.
Seldin DW, Preisig PA, Alpern RJ. Regulation of proximal reabsorption by effective arterial blood volume. Seminars In Nephrology 1991, 11: 212-9. PMID: 2034926.Peer-Reviewed Original ResearchConceptsEffective arterial blood volumeEffective arterial volumeRenal nerve activityProximal tubular transportAtrial natriuretic factorArterial blood volumeLevels of hormonesRenal hemodynamicsNerve activityDietary NaClAngiotensin IIProximal reabsorptionNatriuretic factorBlood volumeTubular transportProximal tubulesChronic effectsArterial volumeOncotic pressureNorepinephrineHemodynamicsEpinephrineHormoneReabsorption