1993
The renal proximal tubule renin-angiotensin system.
Moe O, Alpern R, Henrich W. The renal proximal tubule renin-angiotensin system. Seminars In Nephrology 1993, 13: 552-7. PMID: 8278688.Peer-Reviewed Original ResearchConceptsProximal tubule renin-angiotensin systemProximal tubulesRenin-angiotensin systemAutosomal dominant polycystic kidney diseaseDominant polycystic kidney diseasePolycystic kidney diseaseEssential hypertensionKidney diseasePathogenetic roleRenal vasculatureJG cellsCyst growthMammalian proximal tubuleHypertensionReninTubulesComplete RASPatientsDiseaseAutocrineParacrineRAVasculatureRenin expression in renal proximal tubule.
Moe OW, Ujiie K, Star RA, Miller RT, Widell J, Alpern RJ, Henrich WL. Renin expression in renal proximal tubule. Journal Of Clinical Investigation 1993, 91: 774-779. PMID: 7680667, PMCID: PMC288027, DOI: 10.1172/jci116296.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceBlotting, SouthernCells, CulturedCloning, MolecularColforsinEnalaprilIn Vitro TechniquesIsoproterenolKidney Tubules, ProximalKineticsMaleMolecular Sequence DataMuscle, Smooth, VascularOligodeoxyribonucleotidesPoly APolymerase Chain ReactionRabbitsRatsRats, Sprague-DawleyReninRNARNA, MessengerTranscription, GeneticConceptsProximal tubule cellsCultured proximal tubule cellsRenin-angiotensin systemProximal tubulesRenal proximal tubulesTubule cellsRenin activityLocal renin-angiotensin systemPrimary culturesPresence of reninRabbit proximal tubule cellsAngiotensin-converting enzymeMammalian renal proximal tubulePrevious immunohistochemical studiesSynthesized reninAngiotensin receptorsAngiotensin IIRenin contentPolymerase chain reactionRenin expressionImmunohistochemical studyM isoproterenolM forskolinNormal ratsRenin mRNA
1991
Effects of endothelin on in vitro renin secretion
Moe O, Tejedor A, Campbell WB, Alpern RJ, Henrich WL. Effects of endothelin on in vitro renin secretion. American Journal Of Physiology 1991, 260: e521-e525. PMID: 2018117, DOI: 10.1152/ajpendo.1991.260.4.e521.Peer-Reviewed Original ResearchConceptsRat kidney cortical slicesRenin secretionKidney cortical slicesEndothelin-1Juxtaglomerular cellsRenin releaseCortical slicesRenin inhibitionBasal renin releaseVitro renin secretionBasal renin secretionRenal renin secretionEffects of endothelinIntracellular calcium bufferAddition of isoproterenolMechanism of actionRenin inhibitorsIsoproterenolSecretionCalcium bufferDistinct preparationsBAPTASimilar effectsDirect effectInhibition