1991
Chronic K depletion stimulates rat renal brush-border membrane Na-citrate cotransporter
Levi M, McDonald LA, Preisig PA, Alpern RJ. Chronic K depletion stimulates rat renal brush-border membrane Na-citrate cotransporter. American Journal Of Physiology 1991, 261: f767-f773. PMID: 1683169, DOI: 10.1152/ajprenal.1991.261.5.f767.Peer-Reviewed Original ResearchIncreased Na/H antiporter and Na/3HCO3 symporter activities in chronic hyperfiltration. A model of cell hypertrophy.
Preisig PA, Alpern RJ. Increased Na/H antiporter and Na/3HCO3 symporter activities in chronic hyperfiltration. A model of cell hypertrophy. The Journal Of General Physiology 1991, 97: 195-217. PMID: 1849958, PMCID: PMC2216475, DOI: 10.1085/jgp.97.2.195.Peer-Reviewed Original ResearchConceptsHyperfiltration groupChronic hyperfiltrationNa/H antiporterKidney weightCell hypertrophyHigher glomerular filtration rateNa/H antiporter activityH antiporterGlomerular filtration rateVivo microperfused rat proximal tubuleCell pHRat proximal tubuleSymporter activityFiltration rateProximal tubulesUltrafiltrate-like solutionHyperfiltrationSteady-state cell pHProtein feedingPeritubular perfusateDietary proteinParallel increaseUninephrectomyHypertrophyCell acidificationDietary NaCl modulates Na(+)-H+ antiporter activity in renal cortical apical membrane vesicles
Moe OW, Tejedor A, Levi M, Seldin DW, Preisig PA, Alpern RJ. Dietary NaCl modulates Na(+)-H+ antiporter activity in renal cortical apical membrane vesicles. American Journal Of Physiology 1991, 260: f130-f137. PMID: 1847012, DOI: 10.1152/ajprenal.1991.260.1.f130.Peer-Reviewed Original ResearchConceptsDietary NaClNaCl reabsorptionSystemic acid-base disturbancesExtracellular fluid volume depletionNaHCO3 reabsorptionExtracellular fluid volume expansionFluid volume depletionHigh-salt dietChronic metabolic alkalosisFluid volume expansionAcridine orange fluorescence methodExtracellular fluid volumeAcid-base disturbancesAntiporter activityDietary protocolChronic alterationsVolume depletionMetabolic alkalosisChronic changesHS dietApical membrane vesiclesLS dietFluid volumeRatsReabsorption
1988
Chronic metabolic acidosis causes an adaptation in the apical membrane Na/H antiporter and basolateral membrane Na(HCO3)3 symporter in the rat proximal convoluted tubule.
Preisig PA, Alpern RJ. Chronic metabolic acidosis causes an adaptation in the apical membrane Na/H antiporter and basolateral membrane Na(HCO3)3 symporter in the rat proximal convoluted tubule. Journal Of Clinical Investigation 1988, 82: 1445-1453. PMID: 2844858, PMCID: PMC442703, DOI: 10.1172/jci113750.Peer-Reviewed Original ResearchConceptsChronic metabolic acidosisNa/H antiporterMetabolic acidosisAcidotic animalsH antiporterVivo microperfused rat proximal tubuleDpHi/dtRat proximal tubuleBasolateral membraneTransporter activityDietary acidPeritubular capillariesProximal tubulesNa/HPH-sensitive fluorescent dyeAcidosisTubulesSubsequent studiesAnimalsCarboxy-fluoresceinAbsence of contactCells
1987
Role of the Na+/H+ antiporter in rat proximal tubule bicarbonate absorption.
Preisig PA, Ives HE, Cragoe EJ, Alpern RJ, Rector FC. Role of the Na+/H+ antiporter in rat proximal tubule bicarbonate absorption. Journal Of Clinical Investigation 1987, 80: 970-978. PMID: 2888788, PMCID: PMC442334, DOI: 10.1172/jci113190.Peer-Reviewed Original ResearchApical membrane chloride/base exchange in the rat proximal convoluted tubule.
Alpern RJ. Apical membrane chloride/base exchange in the rat proximal convoluted tubule. Journal Of Clinical Investigation 1987, 79: 1026-1030. PMID: 3558814, PMCID: PMC424279, DOI: 10.1172/jci112914.Peer-Reviewed Original Research
1986
Cell pH in the rat proximal convoluted tubule. Regulation by luminal and peritubular pH and sodium concentration.
Alpern RJ, Chambers M. Cell pH in the rat proximal convoluted tubule. Regulation by luminal and peritubular pH and sodium concentration. Journal Of Clinical Investigation 1986, 78: 502-510. PMID: 3016029, PMCID: PMC423587, DOI: 10.1172/jci112602.Peer-Reviewed Original Research
1985
Mechanism of basolateral membrane H+/OH-/HCO-3 transport in the rat proximal convoluted tubule. A sodium-coupled electrogenic process.
Alpern RJ. Mechanism of basolateral membrane H+/OH-/HCO-3 transport in the rat proximal convoluted tubule. A sodium-coupled electrogenic process. The Journal Of General Physiology 1985, 86: 613-636. PMID: 2999293, PMCID: PMC2228817, DOI: 10.1085/jgp.86.5.613.Peer-Reviewed Original ResearchConceptsUnits/minPeritubular pHHigh extracellular potassium concentrationCell pHSodium concentrationPotassium concentrationExtracellular potassium concentrationBasolateral membranePeritubular potassium concentrationCell depolarizationMeq/Sodium removalCell acidificationTubulesPeritubular fluidTotal absenceSitCellsRatsMinSodiumActive and passive components of chloride transport in the rat proximal convoluted tubule.
Alpern RJ, Howlin KJ, Preisig PA. Active and passive components of chloride transport in the rat proximal convoluted tubule. Journal Of Clinical Investigation 1985, 76: 1360-1366. PMID: 4056034, PMCID: PMC424076, DOI: 10.1172/jci112111.Peer-Reviewed Original ResearchAmiloride inhibition of proximal tubular acidification
Howlin KJ, Alpern RJ, Rector FC. Amiloride inhibition of proximal tubular acidification. American Journal Of Physiology 1985, 248: f773-f778. PMID: 2988347, DOI: 10.1152/ajprenal.1985.248.6.f773.Peer-Reviewed Original ResearchConceptsProximal tubular acidificationLuminal amilorideBicarbonate absorptionX minTubular acidificationM amilorideSodium chloride absorptionLate proximal tubular fluidProximal tubular fluidPerfusion rateProximal acidificationVivo microperfusionTubular fluidKidney cortexChloride absorptionInhibition of acidificationPmol xAmilorideNonspecific inhibitionAmiloride inhibitionGreater inhibitionBrush border membrane vesiclesInhibitionGlucose effluxPotent inhibitor
1984
Bicarbonate-water interactions in the rat proximal convoluted tubule. An effect of volume flux on active proton secretion.
Alpern RJ. Bicarbonate-water interactions in the rat proximal convoluted tubule. An effect of volume flux on active proton secretion. The Journal Of General Physiology 1984, 84: 753-770. PMID: 6096481, PMCID: PMC2228763, DOI: 10.1085/jgp.84.5.753.Peer-Reviewed Original Research
1983
Flow dependence of proximal tubular bicarbonate absorption
Alpern RJ, Cogan MG, Rector FC. Flow dependence of proximal tubular bicarbonate absorption. American Journal Of Physiology 1983, 245: f478-f484. PMID: 6414312, DOI: 10.1152/ajprenal.1983.245.4.f478.Peer-Reviewed Original ResearchMeSH KeywordsAbsorptionAnimalsBicarbonatesBiological TransportCarbon DioxideKidney Tubules, ProximalKineticsMaleModels, BiologicalPerfusionRatsRats, Inbred StrainsConceptsLuminal bicarbonate concentrationBicarbonate absorptionFlow-dependent increaseFlow-dependent decreaseProximal convoluted tubulesBicarbonate concentrationFlow-induced increaseFlow-dependent changesConvoluted tubulesX minPmol xStimulationProton secretionTubulesPerfusion rateMaximal rateObserved stimulationMinEffects of extracellular fluid volume and plasma bicarbonate concentration on proximal acidification in the rat.
Alpern RJ, Cogan MG, Rector FC. Effects of extracellular fluid volume and plasma bicarbonate concentration on proximal acidification in the rat. Journal Of Clinical Investigation 1983, 71: 736-746. PMID: 6826733, PMCID: PMC436924, DOI: 10.1172/jci110821.Peer-Reviewed Original ResearchConceptsNet bicarbonate absorptionExtracellular fluid volumeVolume-expanded ratsLuminal bicarbonate concentrationPlasma bicarbonate concentrationBicarbonate absorptionVolume statusFluid volumeBicarbonate concentrationProton secretionExtracellular fluid volume statusBicarbonate permeabilityFluid volume statusPeritubular bicarbonate concentrationsProximal acidificationHydropenic ratsRatsAcidotic ratsSecretionAbove inhibitionLuminal compositionAlkalosisVolume expansionTubulesMM bicarbonate
1982
Effect of luminal bicarbonate concentration on proximal acidification in the rat
Alpern RJ, Cogan MG, Rector FC. Effect of luminal bicarbonate concentration on proximal acidification in the rat. American Journal Of Physiology 1982, 243: f53-f59. PMID: 7091367, DOI: 10.1152/ajprenal.1982.243.1.f53.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBicarbonatesBiological TransportHydrogen-Ion ConcentrationKidney Tubules, ProximalKineticsMaleRatsRats, Inbred StrainsConceptsLuminal bicarbonate concentrationBicarbonate absorptionBicarbonate concentrationNet bicarbonate absorptionProximal convoluted tubulesProximal tubular acidificationProton secretionBicarbonate leakProximal acidificationTubular acidificationConvoluted tubulesBicarbonate permeabilitySecretionRats