2001
Endothelin-1/endothelin-B receptor–mediated increases in NHE3 activity in chronic metabolic acidosis
Laghmani K, Preisig P, Moe O, Yanagisawa M, Alpern R. Endothelin-1/endothelin-B receptor–mediated increases in NHE3 activity in chronic metabolic acidosis. Journal Of Clinical Investigation 2001, 107: 1563-1569. PMID: 11413164, PMCID: PMC200190, DOI: 10.1172/jci11234.Peer-Reviewed Original ResearchMeSH KeywordsAcidosisAmmoniaAnimalsBicarbonatesChronic DiseaseCitric AcidCulture TechniquesEndothelin-1EndothelinsKidney Tubules, ProximalMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicProtein PrecursorsReceptor, Endothelin BReceptors, EndothelinRNA, MessengerSodiumSodium-Hydrogen Exchanger 3Sodium-Hydrogen ExchangersConceptsTg/tgAcid ingestionTitratable acid excretionMetabolic acidosisNHE3 activityAcid excretionReceptor-deficient miceEndothelin B receptorET-1 expressionChronic metabolic acidosisProximal tubule suspensionsAmmonium excretionM endothelinNa/H antiporterC57BL/6 miceApical membrane NHE3Renal epithelial cellsCultured renal epithelial cellsEndothelin-1/Tubule suspensionsMRNA expressionControl dietMiceExcretionEpithelial cells
1996
Endothelin(B) receptor activates NHE-3 by a Ca2+-dependent pathway in OKP cells.
Chu TS, Peng Y, Cano A, Yanagisawa M, Alpern RJ. Endothelin(B) receptor activates NHE-3 by a Ca2+-dependent pathway in OKP cells. Journal Of Clinical Investigation 1996, 97: 1454-1462. PMID: 8617878, PMCID: PMC507205, DOI: 10.1172/jci118567.Peer-Reviewed Original ResearchConceptsNa/H antiporter activityReceptor blockersET-1OKP cellsET-1-induced increaseEndothelin receptor blockersNHE-3Pertussis toxin pretreatmentSelective receptor blockerAntiporter activationM endothelinPertussis toxinToxin pretreatmentSustained increaseAntiporter isoformsEndothelinTransient increaseAntiporter activityBlockersKinase inhibitorsCyclic GMPAdenylyl cyclaseReceptor cDNADependent pathwayReceptors