Pathogenesis of edema formation in the nephrotic syndrome.
Palmer BF, Alpern RJ. Pathogenesis of edema formation in the nephrotic syndrome. Kidney International Supplement 1997, 59: s21-7. PMID: 9185099.Peer-Reviewed Original ResearchConceptsPlasma oncotic pressureEdema formationNephrotic syndromeOncotic pressurePlasma volumeEffective circulatory volumeMost nephrotic patientsPrimary salt retentionPrimary sodium retentionMinority of patientsCapillary fluid filtrationAtrial natriuretic peptideDevelopment of edemaNeurohumoral markersIntrarenal mechanismsNatriuretic effectNephrotic patientsSodium retentionCirculatory volumeIntravascular volumeNatriuretic peptideEffector mechanismsUrinary lossTubular resistanceIntravascular space