Long-term activation of protein kinase c causes chronic Na/H antiporter stimulation in cultured proximal tubule cells.
Horie S, Moe O, Miller RT, Alpern RJ. Long-term activation of protein kinase c causes chronic Na/H antiporter stimulation in cultured proximal tubule cells. Journal Of Clinical Investigation 1992, 89: 365-372. PMID: 1310692, PMCID: PMC442861, DOI: 10.1172/jci115594.Peer-Reviewed Original ResearchConceptsNa/H antiporter activityProximal tubule cellsCultured proximal tubule cellsLong-term activationTubule cellsProtein kinase CShort-term activationDose-dependent increaseKinase CActivity 24 hActinomycin DAntiporter activityNa/H antiporterChronic conditionsTwo- to threefold increaseAcute increaseEffect of phorbolProtein kinase C activationChronic effectsTransient increaseMicroM cycloheximidePersistent increaseAlpha-PMAKinase C activationChronic regulator