2020
Initial Evaluation of Rapid, Direct-to-Digital Prostate Biopsy Pathology.
Torres R, Olson E, Homer R, Martin DT, Levene MJ, Perincheri S, Sprenkle PC, Humphrey PA. Initial Evaluation of Rapid, Direct-to-Digital Prostate Biopsy Pathology. Archives Of Pathology & Laboratory Medicine 2020, 145: 583-591. PMID: 32991670, DOI: 10.5858/arpa.2020-0037-oa.Peer-Reviewed Original ResearchPrimate model of chronic retinal neovascularization and vascular leakage
Patel C, Goody R, Hu W, Kurian A, James D, Torres R, Christie LA, Hohman T, Lawrence M. Primate model of chronic retinal neovascularization and vascular leakage. Experimental Eye Research 2020, 195: 108031. PMID: 32275921, PMCID: PMC7335215, DOI: 10.1016/j.exer.2020.108031.Peer-Reviewed Original ResearchConceptsGlial fibrillary acidic proteinVascular leakageVon Willebrand factorOptical coherence tomographyFluorescein angiographyRetinal neovascularizationPrimate modelCD105/endoglinNeovascular diseasesRetinal degenerationDL-alpha-aminoadipic acidBilateral intravitreal injectionsInner retinal edemaRetinal vascular leakageRetinal vascular pathologyVascular disease mechanismsColor fundus photographyMüller cell lossFibrillary acidic proteinExpression of vWFAfrican green monkeysCD68 immunoreactivityMacular telangiectasiaRetinal edemaIntravitreal injection
2018
Modified approach to fibrinogen replacement in the setting of dysfibrinogenaemia
Chandler JB, Siddon AJ, Bahel P, Torres R, Rinder HM, Tormey CA. Modified approach to fibrinogen replacement in the setting of dysfibrinogenaemia. Journal Of Clinical Pathology 2018, 72: 177. PMID: 30463936, DOI: 10.1136/jclinpath-2018-205438.Peer-Reviewed Original ResearchFalse-Positive Light Chain Clonal Restriction by Flow Cytometry in Patients Treated With Alemtuzumab
Chen PP, Tormey CA, Eisenbarth SC, Torres R, Richardson SS, Rinder HM, Smith BR, Siddon AJ. False-Positive Light Chain Clonal Restriction by Flow Cytometry in Patients Treated With Alemtuzumab. American Journal Of Clinical Pathology 2018, 151: 154-163. PMID: 30307483, DOI: 10.1093/ajcp/aqy129.Peer-Reviewed Original ResearchConceptsHealthy donor bloodAlemtuzumab treatmentDonor bloodBone marrowFlow cytometryLight chain restrictionT-cell prolymphocytic leukemiaB-cell neoplasmsLight chain clonalityFlow cytometry analysisAutoimmune diseasesHematologic malignanciesImmunophenotypic analysisChain restrictionAlemtuzumabT cellsB cellsProlymphocytic leukemiaImmunoglobulin G1PatientsMonoclonal antibodiesCytometry analysisSimilar findingsBloodClonal restrictionMcp1 Promotes Macrophage-Dependent Cyst Expansion in Autosomal Dominant Polycystic Kidney Disease
Cassini MF, Kakade VR, Kurtz E, Sulkowski P, Glazer P, Torres R, Somlo S, Cantley LG. Mcp1 Promotes Macrophage-Dependent Cyst Expansion in Autosomal Dominant Polycystic Kidney Disease. Journal Of The American Society Of Nephrology 2018, 29: 2471-2481. PMID: 30209078, PMCID: PMC6171277, DOI: 10.1681/asn.2018050518.Peer-Reviewed Original ResearchConceptsAutosomal dominant polycystic kidney diseaseSingle knockout miceTubular cell injuryDominant polycystic kidney diseaseCyst growthPolycystic kidney diseaseKidney diseaseCell injuryMonocyte chemoattractant protein-1Alternative activation phenotypeChemoattractant protein-1Double knockout miceOrthologous mouse modelCell proliferative rateRenal functionMacrophage accumulationMacrophage infiltrationReceptor CCR2Cystic dilationMacrophage numbersFunctional improvementOxidative DNA damageMouse modelActivation phenotypeCyst expansion
2014
Abnormal lymphocytes with “filamentous-like” cytoplasmic inclusions in chronic lymphocytic leukemia
Torres R, Tormey CA. Abnormal lymphocytes with “filamentous-like” cytoplasmic inclusions in chronic lymphocytic leukemia. Blood 2014, 124: 1391. PMID: 25313413, PMCID: PMC4148760, DOI: 10.1182/blood-2014-06-582098.Peer-Reviewed Original ResearchLupus anticoagulant testing and anticoagulation do not mix: quantitation of discrepant results and potential approaches to reduce false positives
Chandler JB, Torres R, Rinder HM, Tormey CA. Lupus anticoagulant testing and anticoagulation do not mix: quantitation of discrepant results and potential approaches to reduce false positives. British Journal Of Haematology 2014, 167: 704-707. PMID: 25041401, PMCID: PMC7024602, DOI: 10.1111/bjh.13030.Peer-Reviewed Original Research
2013
High-Resolution, 2- and 3-Dimensional Imaging of Uncut, Unembedded Tissue Biopsy Samples
Torres R, Vesuna S, Levene MJ. High-Resolution, 2- and 3-Dimensional Imaging of Uncut, Unembedded Tissue Biopsy Samples. Archives Of Pathology & Laboratory Medicine 2013, 138: 395-402. PMID: 23829375, DOI: 10.5858/arpa.2013-0094-oa.Peer-Reviewed Original ResearchConceptsImmediate therapeutic decisionsPractical clinical toolComprehensive visual examinationTissue biopsy samplesBiopsy specimensKidney specimensAncillary studiesGold standard techniqueTherapeutic decisionsRenal tissueBiopsy samplesHematoxylin-eosinHuman prostateMorphologic effectsNormal reactivityClinical settingClinical toolMultiphoton microscopyPathology samplesHistologic techniquesPreservation of tissuesExcellent morphologic detailTraditional histologyFurther investigationTissue
2012
Normalized CCND1 expression has prognostic value in mantle cell lymphoma
Siddon AJ, Torres R, Rinder HM, Smith BR, Howe JG, Tormey CA. Normalized CCND1 expression has prognostic value in mantle cell lymphoma. British Journal Of Haematology 2012, 158: 551-553. PMID: 22671703, DOI: 10.1111/j.1365-2141.2012.09181.x.Peer-Reviewed Original Research
2011
Multiphoton fluorescence, second harmonic generation, and fluorescence lifetime imaging of whole cleared mouse organs
Vesuna S, Torres R, Levene MJ. Multiphoton fluorescence, second harmonic generation, and fluorescence lifetime imaging of whole cleared mouse organs. Journal Of Biomedical Optics 2011, 16: 106009-106009-6. PMID: 22029356, DOI: 10.1117/1.3641992.Peer-Reviewed Original ResearchColonic in situ mantle cell lymphoma
Neto AG, Oroszi G, Protiva P, Rose M, Shafi N, Torres R. Colonic in situ mantle cell lymphoma. Annals Of Diagnostic Pathology 2011, 16: 508-514. PMID: 21840231, DOI: 10.1016/j.anndiagpath.2011.05.001.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorBiopsyCarcinoma in SituChromosomes, Human, Pair 11Chromosomes, Human, Pair 14Colonic NeoplasmsColonoscopyCyclin D1Disease ProgressionHumansIn Situ Hybridization, FluorescenceIntestinal MucosaLymph NodesLymphoma, Mantle-CellMaleMiddle AgedRetrospective StudiesTranslocation, GeneticConceptsMantle cell lymphomaSitu mantle cell lymphomaColonic biopsiesLymphoid aggregatesCell lymphomaCyclin D1-positive cellsPrimary GI lymphomaSmall lymphoid aggregatesBenign colonic mucosaGI lymphomaSitu lymphomaUnderwent colonoscopyLymph nodesRandom biopsiesIleocolic intussusceptionColonic mucosaGastrointestinal tractPositive cellsBiopsyLymphomaPleomorphic morphologyCyclin D1Situ hybridization analysisFirst caseSecond presentation