K+ Channel Mutations in Adrenal Aldosterone-Producing Adenomas and Hereditary Hypertension
Choi M, Scholl UI, Yue P, Björklund P, Zhao B, Nelson-Williams C, Ji W, Cho Y, Patel A, Men CJ, Lolis E, Wisgerhof MV, Geller DS, Mane S, Hellman P, Westin G, Åkerström G, Wang W, Carling T, Lifton RP. K+ Channel Mutations in Adrenal Aldosterone-Producing Adenomas and Hereditary Hypertension. Science 2011, 331: 768-772. PMID: 21311022, PMCID: PMC3371087, DOI: 10.1126/science.1198785.Peer-Reviewed Original ResearchMeSH KeywordsAdrenal Cortex NeoplasmsAdrenal GlandsAdrenocortical AdenomaAldosteroneCell LineCell ProliferationFemaleG Protein-Coupled Inwardly-Rectifying Potassium ChannelsHumansHyperaldosteronismHyperplasiaHypertensionMaleMutant ProteinsMutationPotassiumProtein MultimerizationSodiumZona GlomerulosaConceptsAldosterone-producing adrenal adenomaSevere hypertensionCell proliferationHormone productionAdrenal aldosterone-producing adenomaBilateral adrenal hyperplasiaSubset of patientsAldosterone-producing adenomaAdrenal glomerulosa cellsAdrenal adenomaAldosterone productionEndocrine tumorsGlomerulosa cellsAdrenal hyperplasiaRecurrent somatic mutationsCalcium entryKCNJ5 mutationsHypertensionCell depolarizationHereditary hypertensionChannel mutationsSomatic mutationsAdenomasMendelian formsSodium conductance