2003
Synthesis and Evaluation of B-, C-, and D-Ring-Substituted Estradiol Carboxylic Acid Esters as Locally Active Estrogens
Labaree DC, Zhang JX, Harris HA, O'Connor C, Reynolds TY, Hochberg RB. Synthesis and Evaluation of B-, C-, and D-Ring-Substituted Estradiol Carboxylic Acid Esters as Locally Active Estrogens. Journal Of Medicinal Chemistry 2003, 46: 1886-1904. PMID: 12723952, DOI: 10.1021/jm0204340.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding, CompetitiveEsterasesEstersEstradiolEstradiol CongenersEstrogen Receptor alphaEstrogen Receptor betaFemaleHumansIn Vitro TechniquesKidneyLigandsMiceMicrosomesOrgan SizeOxidoreductasesRatsRats, Sprague-DawleyReceptors, EstrogenStructure-Activity RelationshipTumor Cells, CulturedUterusVaginaConceptsEstrogen receptorHormonal activityReceptor bindingAnalogues of estradiolEstrogen-sensitive genesEstrogen receptor bindingEstrogen-responsive genesEstrogenic actionIshikawa cellsEffective estrogenActive estrogensEstrogenHormonal actionDerivatives of estradiolEstradiolEstrogenic responsesSystemic actionReceptorsEstrogenic activityVivo assaysNonspecific esterasesSteroid nucleusSensitive genesActivitySteroid ring
1992
Estrogen receptors colocalize with low-affinity nerve growth factor receptors in cholinergic neurons of the basal forebrain.
Toran-Allerand CD, Miranda RC, Bentham WD, Sohrabji F, Brown TJ, Hochberg RB, MacLusky NJ. Estrogen receptors colocalize with low-affinity nerve growth factor receptors in cholinergic neurons of the basal forebrain. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 4668-4672. PMID: 1316615, PMCID: PMC49144, DOI: 10.1073/pnas.89.10.4668.Peer-Reviewed Original ResearchConceptsLow-affinity nerve growth factor receptorNerve growth factor receptorGrowth factor receptorBasal forebrainCholinergic neuronsSame neuronsFactor receptorCholinergic marker enzyme choline acetyltransferaseGonadal steroid hormone estrogenBrain-derived neurotrophic factorPrimate basal forebrainRodent basal forebrainSteroid hormone estrogenEnzyme choline acetyltransferaseNerve growth factorSitu hybridization histochemistryEstrogen deficiencyNeurotrophic factorNeurotrophin-3Cholinergic functionCholine acetyltransferaseNeuronal survivalHormone estrogenEstrogen receptorClinical conditions