2004
Estrogen to Antiestrogen with a Single Methylene Group Resulting in an Unusual Steroidal Selective Estrogen Receptor Modulator
Zhang JX, Labaree DC, Mor G, Hochberg RB. Estrogen to Antiestrogen with a Single Methylene Group Resulting in an Unusual Steroidal Selective Estrogen Receptor Modulator. The Journal Of Clinical Endocrinology & Metabolism 2004, 89: 3527-3535. PMID: 15240642, DOI: 10.1210/jc.2003-032005.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBody WeightBone and BonesCell Line, TumorCholesterolDose-Response Relationship, DrugEstradiolEstrogen AntagonistsEstrogen Receptor alphaEstrogen Receptor betaEstrogensFemaleHumansHydrocarbonsMethaneOrgan SizeRatsRats, Sprague-DawleyReceptors, EstrogenSelective Estrogen Receptor ModulatorsTransfectionUterusConceptsSelective estrogen receptor modulatorsEstrogen receptor modulatorsReceptor modulatorsBreast cancer preventionEstradiol-induced proliferationER affinityHigh ER affinityImportant therapeutic agentsPlasma cholesterolER alphaCancer preventionEstrogen agonistEstrogenic agonistTherapeutic agentsEstradiol analogsHigh estrogenic potencyCell bioassayBone growthEstrogenic activityAntiestrogensEstrogenic potencyAgonistsCritical structuresUnique mechanismGroup
2003
Synthesis and Evaluation of B-, C-, and D-Ring-Substituted Estradiol Carboxylic Acid Esters as Locally Active Estrogens
Labaree DC, Zhang JX, Harris HA, O'Connor C, Reynolds TY, Hochberg RB. Synthesis and Evaluation of B-, C-, and D-Ring-Substituted Estradiol Carboxylic Acid Esters as Locally Active Estrogens. Journal Of Medicinal Chemistry 2003, 46: 1886-1904. PMID: 12723952, DOI: 10.1021/jm0204340.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding, CompetitiveEsterasesEstersEstradiolEstradiol CongenersEstrogen Receptor alphaEstrogen Receptor betaFemaleHumansIn Vitro TechniquesKidneyLigandsMiceMicrosomesOrgan SizeOxidoreductasesRatsRats, Sprague-DawleyReceptors, EstrogenStructure-Activity RelationshipTumor Cells, CulturedUterusVaginaConceptsEstrogen receptorHormonal activityReceptor bindingAnalogues of estradiolEstrogen-sensitive genesEstrogen receptor bindingEstrogen-responsive genesEstrogenic actionIshikawa cellsEffective estrogenActive estrogensEstrogenHormonal actionDerivatives of estradiolEstradiolEstrogenic responsesSystemic actionReceptorsEstrogenic activityVivo assaysNonspecific esterasesSteroid nucleusSensitive genesActivitySteroid ring
1989
The synthesis of 11 beta-methoxy-[16 alpha-123I] iodoestradiol and its interaction with the estrogen receptor in vivo and in vitro.
Zielinski JE, Larner JM, Hoffer PB, Hochberg RB. The synthesis of 11 beta-methoxy-[16 alpha-123I] iodoestradiol and its interaction with the estrogen receptor in vivo and in vitro. Journal Of Nuclear Medicine 1989, 30: 209-15. PMID: 2738649.Peer-Reviewed Original Research
1982
Estradiol fatty acid esters. The isolation and identification of the lipoidal derivative of estradiol synthesized in the bovine uterus.
Mellon-Nussbaum SH, Ponticorvo L, Schatz F, Hochberg RB. Estradiol fatty acid esters. The isolation and identification of the lipoidal derivative of estradiol synthesized in the bovine uterus. Journal Of Biological Chemistry 1982, 257: 5678-5684. PMID: 7068614, DOI: 10.1016/s0021-9258(19)83831-0.Peer-Reviewed Original Research