2023
Physician Preferences when Selecting Candidates for Lower-Quality Kidney Offers
Sepulveda J, Mehrotra S, Yang J, Schantz K, Becker Y, Formica R, Ladner D, Kaufman D, Friedewald J. Physician Preferences when Selecting Candidates for Lower-Quality Kidney Offers. Clinical Journal Of The American Society Of Nephrology 2023, 18: 1599-1609. PMID: 37729938, PMCID: PMC10723918, DOI: 10.2215/cjn.0000000000000302.Peer-Reviewed Original ResearchConceptsCold ischemia timePanel reactive antibodyIschemia timeMarginal kidneysEjection fractionReactive antibodiesRecipient characteristicsPost-transplant survival scoreSignificant associationKidney Donor Profile IndexKarnofsky performance scoreSerum creatinine levelsHistory of diabetesLow-quality kidneysHLA mismatchesPerformance statusRecipient ageCreatinine levelsDiabetes statusHLA matchCirculatory deathKidney qualityYounger recipientsDonor ageDiscrete choice experimentStakeholders’ perspectives on transplant metrics: the 2022 Scientific Registry of Transplant Recipients’ consensus conference
Snyder J, Schaffhausen C, Hart A, Axelrod D, Dils D, Formica R, Gaber A, Hunt H, Jones J, Mohan S, Patzer R, Pinney S, Ratner L, Slaker D, Stewart D, Stewart Z, Van Slyck S, Kasiske B, Hirose R, Israni A. Stakeholders’ perspectives on transplant metrics: the 2022 Scientific Registry of Transplant Recipients’ consensus conference. American Journal Of Transplantation 2023, 23: 875-890. PMID: 36958628, DOI: 10.1016/j.ajt.2023.03.012.Peer-Reviewed Original ResearchMeSH KeywordsBenchmarkingHumansLiving DonorsRegistriesTissue and Organ ProcurementTissue DonorsTransplant RecipientsTransplantsThe Unintended Consequences of Changes to the Organ Allocation Policy
Formica R, Schold J. The Unintended Consequences of Changes to the Organ Allocation Policy. Journal Of The American Society Of Nephrology 2023, 34: 14-16. PMID: 36719146, PMCID: PMC10101628, DOI: 10.1681/asn.0000000000000009.Peer-Reviewed Original Research
2022
A Composite End Point of Graft Status and eGFR at 1 Year to Improve the Scientific Registry of Transplant Recipients’ Five-Tier Rating System
Wang K, Deng Y, Stewart D, Formica R. A Composite End Point of Graft Status and eGFR at 1 Year to Improve the Scientific Registry of Transplant Recipients’ Five-Tier Rating System. Journal Of The American Society Of Nephrology 2022, 33: 1613-1624. PMID: 35537779, PMCID: PMC9342646, DOI: 10.1681/asn.2022010078.Peer-Reviewed Original ResearchMeSH KeywordsGraft SurvivalHumansKidney TransplantationRegistriesTissue DonorsTransplant RecipientsTreatment OutcomeUnited StatesConceptsComposite end pointTraditional end pointsTransplant programsEnd pointAllograft functionGraft survivalScientific RegistryFive-tier systemLong-term graft outcomeDonor graft survivalKidney transplant programAllograft failureAllograft survivalGraft outcomeTransplant recipientsGraft statusGraft failureEGFR differenceSRTR dataSurvival rateEGFRSurvivalRegistryMeaningful differencesConcept study
2020
Physician and patient acceptance of policies to reduce kidney discard
Mehrotra S, Schantz K, Friedewald JJ, Ladner DP, Becker Y, Formica R, Barah M, Gu J, Gordon EJ. Physician and patient acceptance of policies to reduce kidney discard. Clinical Transplantation 2020, 34: e14054. PMID: 32738167, PMCID: PMC7929781, DOI: 10.1111/ctr.14054.Peer-Reviewed Original ResearchConceptsDeceased donor kidneysMajority of physiciansDonor kidneysKidney allocation policyShortage of kidneysRisk of discardAggressive centersGraft failureSurvival benefitSuitable patientsTransplant physiciansPatient acceptancePatientsKidneyPhysiciansPatient organizationsProfessional societiesKDPITransplantationMajorityMonthsA call to action: Feasible strategies to reduce the discard of transplantable kidneys in the United States
Stewart ZA, Shah SA, Formica RN, Kandaswamy R, Paramesh AS, Friedman J, Squires R, Cooper M, Axelrod DA. A call to action: Feasible strategies to reduce the discard of transplantable kidneys in the United States. Clinical Transplantation 2020, 34: e13990. PMID: 32621660, DOI: 10.1111/ctr.13990.Peer-Reviewed Original ResearchConceptsOrgan utilizationHigh-kidney donor profile index kidneysAcceptable post-transplant outcomesLow-risk organPost-transplant outcomesCold ischemic timeCold ischemia timeDeceased donor kidneysKidney allocation systemHigher transplant ratesNew allocation policyOrgan acceptanceIschemic timeDonor kidneysIschemia timeTransplant ratesOrgan discardRisk organsPractice patternsTransplantable kidneysClinical practicePathological interpretationGeographic sharingKidneyFinancial barriersThe Broader Sharing of Deceased Donor Kidneys Is an Ethical and Legal Imperative
Klarman SE, Formica RN. The Broader Sharing of Deceased Donor Kidneys Is an Ethical and Legal Imperative. Journal Of The American Society Of Nephrology 2020, 31: asn.2020020121. PMID: 32312798, PMCID: PMC7269362, DOI: 10.1681/asn.2020020121.Commentaries, Editorials and Letters
2019
Transplantation of Kidneys from HCV Viremic Donors in the United States: A Missed Opportunity to Inform Clinical Decision Making and Health Policy
Gill JS, Formica RN, Levitsky J. Transplantation of Kidneys from HCV Viremic Donors in the United States: A Missed Opportunity to Inform Clinical Decision Making and Health Policy. Journal Of The American Society Of Nephrology 2019, 30: 1778-1780. PMID: 31570540, PMCID: PMC6779353, DOI: 10.1681/asn.2019070726.Peer-Reviewed Original Research
2018
Report of National Kidney Foundation Consensus Conference to Decrease Kidney Discards
Cooper M, Formica R, Friedewald J, Hirose R, O’Connor K, Mohan S, Schold J, Axelrod D, Pastan S. Report of National Kidney Foundation Consensus Conference to Decrease Kidney Discards. Clinical Transplantation 2018, 33: e13419. PMID: 30345720, DOI: 10.1111/ctr.13419.Peer-Reviewed Original ResearchAnd equal access for all? The future of deceased donor kidney allocation
Formica RN. And equal access for all? The future of deceased donor kidney allocation. American Journal Of Transplantation 2018, 18: 1837-1838. PMID: 29878578, DOI: 10.1111/ajt.14964.Peer-Reviewed Original ResearchSolid organ transplantation of viral hepatitis C positive donor organs into viral hepatitis C negative recipients
Liapakis A, Formica RN, Levitsky J. Solid organ transplantation of viral hepatitis C positive donor organs into viral hepatitis C negative recipients. Current Opinion In Organ Transplantation 2018, 23: 257-263. PMID: 29432255, DOI: 10.1097/mot.0000000000000504.Peer-Reviewed Original ResearchConceptsViremic donorsHepatitis CWaitlist mortalityHepatitis C viremic donorsEarly trial dataHCV-negative recipientsTransplantation of graftsHepatitis C therapySolid organ transplantsSolid organ transplantationUtilization of graftsFormal clinical trialsNet overall reductionGraft utilizationNonviremic recipientsTransplant recipientsC therapyNegative patientsAntiviral therapyNegative recipientsTransplantation ratesClinical trialsOrgan poolDonor organsOrgan transplantation
2017
Transition probabilities between changing sensitization levels, waitlist activity status and competing-risk kidney transplant outcomes using multi-state modeling
Kulkarni S, Hall I, Formica R, Thiessen C, Stewart D, Gan G, Greene E, Deng Y. Transition probabilities between changing sensitization levels, waitlist activity status and competing-risk kidney transplant outcomes using multi-state modeling. PLOS ONE 2017, 12: e0190277. PMID: 29287087, PMCID: PMC5747475, DOI: 10.1371/journal.pone.0190277.Peer-Reviewed Original ResearchConceptsTransplant probabilityTransplant outcomesActivity statusKidney transplant outcomesKAS implementationPost-KASWaitlist mortalityPatient characteristicsOPTN databaseMulti-state modelingStatistical differenceSensitization levelOutcomesTransplantCohortImpact outcomesCPRAStatus combinationsStatusMortalityWhitesSensitizationResponse to: HCV viremic donors with hepatic bridging fibrosis: Are we ready to use their livers in the era of direct-acting antivirals?
Levitsky J, Formica R. Response to: HCV viremic donors with hepatic bridging fibrosis: Are we ready to use their livers in the era of direct-acting antivirals? American Journal Of Transplantation 2017, 17: 2988. PMID: 28858416, DOI: 10.1111/ajt.14478.Peer-Reviewed Original ResearchThe American Society of Transplantation Consensus Conference on the Use of Hepatitis C Viremic Donors in Solid Organ Transplantation
Levitsky J, Formica R, Bloom R, Charlton M, Curry M, Friedewald J, Friedman J, Goldberg D, Hall S, Ison M, Kaiser T, Klassen D, Klintmalm G, Kobashigawa J, Liapakis A, O’Conner K, Reese P, Stewart D, Terrault N, Theodoropoulos N, Trotter J, Verna E, Volk M. The American Society of Transplantation Consensus Conference on the Use of Hepatitis C Viremic Donors in Solid Organ Transplantation. American Journal Of Transplantation 2017, 17: 2790-2802. PMID: 28556422, DOI: 10.1111/ajt.14381.Peer-Reviewed Original ResearchMeSH KeywordsHepacivirusHepatitis CHumansOrgan TransplantationSocieties, MedicalTissue DonorsViremiaConceptsSolid organ transplantationOrgan transplantationHepatitis C viremic donorsHepatitis C virus infectionEnd-stage organ diseaseHCV-viremic organsHCV-viremic patientsProspective research protocolC virus infectionChronic HCV infectionAmerican SocietyViremic donorsViremic organsViremic recipientsHCV infectionHepatitis CTransplant waitlistMeeting of expertsOrgan diseaseVirus infectionOrgan transplantsYoung donorsAntiviral agentsConsensus conferenceTransplantationUtility of Applying Quality Assessment Tools for Kidneys With KDPI ≥80
Doshi MD, Reese PP, Hall IE, Schröppel B, Ficek J, Formica RN, Weng FL, Hasz RD, Thiessen-Philbrook H, Parikh C. Utility of Applying Quality Assessment Tools for Kidneys With KDPI ≥80. Transplantation 2017, 101: 1125-1133. PMID: 27490414, PMCID: PMC5290306, DOI: 10.1097/tp.0000000000001388.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBiomarkersBiopsyDecision Support TechniquesDonor SelectionFemaleGraft SurvivalHumansKaplan-Meier EstimateKidneyKidney TransplantationMaleMiddle AgedPredictive Value of TestsProcess Assessment, Health CareProspective StudiesQuality Indicators, Health CareRisk AssessmentRisk FactorsTissue DonorsTissue SurvivalTreatment OutcomeUnited StatesConceptsKidney Donor Profile IndexGroup 1High kidney donor profile indexDonor kidney poolViability of kidneysGlomerular filtration rateOutcomes of kidneysNumber of kidneysQuality assessment toolKidney poolViable kidneysBiopsy findingsGraft failureRenal resistanceDeceased donorsMulticenter studyFiltration rateBiomarker levelsGroup 3Kidney abnormalitiesKidneySignificant differencesHigh rateAssessment toolProfile indexOpportunities to Increase Availability of Deceased Donor Kidneys
Formica RN. Opportunities to Increase Availability of Deceased Donor Kidneys. Clinical Journal Of The American Society Of Nephrology 2017, 12: 871-873. PMID: 28546441, PMCID: PMC5460703, DOI: 10.2215/cjn.04490417.Peer-Reviewed Original Research
2016
A critical assessment on kidney allocation systems
Formica RN. A critical assessment on kidney allocation systems. Transplantation Reviews 2016, 31: 61-67. PMID: 27919635, DOI: 10.1016/j.trre.2016.10.002.Peer-Reviewed Original ResearchConceptsKidney allocation systemKidney allocationKidney Donor Profile IndexNew kidney allocation systemDelayed graft functionCold ischemic timeDeceased donor kidneysNumber of transplantsOrgan procurement organizationsGraft functionKidney transplantationIschemic timeDonor kidneysTransplant centersOrgan discard ratesClose monitoringMedical needKidneyProcurement organizationsPatientsTransplantationAllocation systemLife savingSignificant declineProfile indexEculizumab Therapy for Chronic Antibody‐Mediated Injury in Kidney Transplant Recipients: A Pilot Randomized Controlled Trial
Kulkarni S, Kirkiles‐Smith N, Deng YH, Formica RN, Moeckel G, Broecker V, Bow L, Tomlin R, Pober JS. Eculizumab Therapy for Chronic Antibody‐Mediated Injury in Kidney Transplant Recipients: A Pilot Randomized Controlled Trial. American Journal Of Transplantation 2016, 17: 682-691. PMID: 27501352, DOI: 10.1111/ajt.14001.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAntibodies, Monoclonal, HumanizedChronic DiseaseComplement C5Complement Inactivating AgentsEarly Intervention, EducationalFemaleFollow-Up StudiesGlomerular Filtration RateGraft RejectionGraft SurvivalHumansIsoantibodiesKidney Failure, ChronicKidney Function TestsKidney TransplantationLiving DonorsMaleMiddle AgedPilot ProjectsPrognosisRisk FactorsTissue DonorsTransplant RecipientsYoung AdultConceptsDe novo donor-specific antibodiesComplement inhibitionTreatment groupsNovo donor-specific antibodiesAntibody-Mediated InjuryC1q-positive patientsDonor-specific antibodiesKidney transplant recipientsPrimary end pointEndothelial cell injuryMo of observationEculizumab therapyEculizumab treatmentHumoral injuryTransplant recipientsKidney transplantRenal functionKidney functionChronic settingEGFR trajectoriesTreatment periodCell injuryPatientsEnd pointPercentage changeSimultaneous Liver–Kidney Allocation: Let′s Not Make Perfect the Enemy of Good
Formica RN. Simultaneous Liver–Kidney Allocation: Let′s Not Make Perfect the Enemy of Good. American Journal Of Transplantation 2016, 16: 2765. PMID: 27184986, DOI: 10.1111/ajt.13873.Peer-Reviewed Original ResearchChanges in Deceased Donor Kidney Transplantation One Year After KAS Implementation
Stewart DE, Kucheryavaya AY, Klassen DK, Turgeon NA, Formica RN, Aeder MI. Changes in Deceased Donor Kidney Transplantation One Year After KAS Implementation. American Journal Of Transplantation 2016, 16: 1834-1847. PMID: 26932731, DOI: 10.1111/ajt.13770.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedCadaverChildChild, PreschoolDelayed Graft FunctionDonor SelectionFemaleGovernment RegulationGraft SurvivalHealth Plan ImplementationHumansInfantInfant, NewbornKidney TransplantationMaleMiddle AgedRetrospective StudiesTime FactorsTissue and Organ ProcurementTissue DonorsUnited StatesYoung AdultConceptsKidney allocation systemDelayed graft function ratesNew kidney allocation systemGraft function rateGraft survival ratesCold ischemic timeKAS implementationLongevity matchingRecipient ageIschemic timeDonor kidneysSubsequent taperingFunction rateRecipient characteristicsOrgan procurementSurvival rateTransplantOne-yearBolus effectRecipientsKidneyDialysisExtended durationEarly impactYears