Circulating NK cells establish tissue residency upon acute infection of skin and mediate accelerated effector responses to secondary infection
Torcellan T, Friedrich C, Doucet-Ladevèze R, Ossner T, Solé V, Riedmann S, Ugur M, Imdahl F, Rosshart S, Arnold S, de Agüero M, Gagliani N, Flavell R, Backes S, Kastenmüller W, Gasteiger G. Circulating NK cells establish tissue residency upon acute infection of skin and mediate accelerated effector responses to secondary infection. Immunity 2023, 57: 124-140.e7. PMID: 38157853, PMCID: PMC10783803, DOI: 10.1016/j.immuni.2023.11.018.Peer-Reviewed Original ResearchConceptsNK cellsTrNK cellsAcute infectionTissue residencySecondary infectionTissue-resident NK cellsConventional NK cellsDistinct developmental requirementsNK cell responsesNatural killer cellsTranscriptional regulator Blimp1Effector cellsKiller cellsCNK cellsPrevious infectionEffector responsesEffector functionsBacterial infectionsCell responsesInfectionRestricted expressionTerms of ontogenyTissueCell formationHuman tissues