2017
Long-term outcomes of tissue-based ACTH-antibody assay-guided transsphenoidal resection of pituitary adenomas in Cushing disease.
Erfe JM, Perry A, McClaskey J, Inzucchi SE, James WS, Eid T, Bronen RA, Mahajan A, Huttner A, Santos F, Spencer D. Long-term outcomes of tissue-based ACTH-antibody assay-guided transsphenoidal resection of pituitary adenomas in Cushing disease. Journal Of Neurosurgery 2017, 129: 629-641. PMID: 29027854, DOI: 10.3171/2017.3.jns162245.Peer-Reviewed Original ResearchConceptsTranssphenoidal resectionMRI studiesCushing's diseaseCortisol levelsLong-term corticosteroid therapyUrinary free cortisol levelsLong-term disease remissionLong-term patient outcomesResults Fourteen patientsLong-term outcomesPostoperative MRI studiesSurgical tumor samplesFree cortisol levelsPreoperative MRI studiesPrecise tumor localizationACTH antibodiesPituitary microCorticosteroid therapyStudy patientsDisease remissionFourteen patientsRemission rateRetrospective reviewTreatment failureCure rate
2004
Long-term outcome after epilepsy surgery for focal cortical dysplasia.
Cohen-Gadol AA, Ozduman K, Bronen RA, Kim JH, Spencer DD. Long-term outcome after epilepsy surgery for focal cortical dysplasia. Journal Of Neurosurgery 2004, 101: 55-65. PMID: 15255252, DOI: 10.3171/jns.2004.101.1.0055.Peer-Reviewed Original ResearchConceptsFocal cortical dysplasiaImproved seizure outcomeLong-term outcomesCortical dysplasiaClear marginsEpileptogenic zoneSeizure outcomeMean ageMean durationRisk factorsCortical developmentIntracranial monitoringObvious risk factorsRare disabling seizuresTransient sensorimotor deficitsMultiple subpial transectionsSubgroup of patientsExtent of resectionVisual field defectsInclusion of patientsNormal functional anatomyReports of outcomesMagnetic resonance imagingFunctional MR imagingPartial lesionectomy
1998
Surgical outcome in occipital lobe epilepsy: Implications for pathophysiology
Aykut‐Bingol C, Bronen R, Kim J, Spencer D, Spencer S. Surgical outcome in occipital lobe epilepsy: Implications for pathophysiology. Annals Of Neurology 1998, 44: 60-69. PMID: 9667593, DOI: 10.1002/ana.410440112.Peer-Reviewed Original ResearchConceptsOccipital lobe epilepsyClinical seizure characteristicsFocal cortical dysplasiaLobe epilepsyLobe locationPathological substrateSeizure characteristicsSurgical outcomesCortical dysplasiaSurgical approachSurgical proceduresRefractory occipital lobe epilepsyDevelopmental abnormalitiesOccipital lobe seizuresChronic inflammatory changesSturge-Weber syndromeMain pathological substrateOccipital lobe tumorElectroclinical variablesElectroclinical featuresMost patientsSeizure controlChronic epilepsyInflammatory changesLobe tumors