2018
Presurgical language fMRI: Technical practices in epilepsy surgical planning
Benjamin CFA, Dhingra I, Li AX, Blumenfeld H, Alkawadri R, Bickel S, Helmstaedter C, Meletti S, Bronen RA, Warfield SK, Peters JM, Reutens D, Połczyńska MM, Hirsch LJ, Spencer DD. Presurgical language fMRI: Technical practices in epilepsy surgical planning. Human Brain Mapping 2018, 39: 4032-4042. PMID: 29962111, PMCID: PMC6175127, DOI: 10.1002/hbm.24229.Peer-Reviewed Original ResearchConceptsLanguage functional MRIFunctional MRISurgical planningEpilepsy surgical planningEpilepsy surgical programsGeneral linear modelingBlood flowClinical practicePatient careSurgical programsRoutine useMarked heterogeneityClinical applicationVerbal fluencyData highlightFMRI dataMost programsPatientsWidespread useEpilepsyIndividualsMRICare
2017
Long-term outcomes of tissue-based ACTH-antibody assay-guided transsphenoidal resection of pituitary adenomas in Cushing disease.
Erfe JM, Perry A, McClaskey J, Inzucchi SE, James WS, Eid T, Bronen RA, Mahajan A, Huttner A, Santos F, Spencer D. Long-term outcomes of tissue-based ACTH-antibody assay-guided transsphenoidal resection of pituitary adenomas in Cushing disease. Journal Of Neurosurgery 2017, 129: 629-641. PMID: 29027854, DOI: 10.3171/2017.3.jns162245.Peer-Reviewed Original ResearchConceptsTranssphenoidal resectionMRI studiesCushing's diseaseCortisol levelsLong-term corticosteroid therapyUrinary free cortisol levelsLong-term disease remissionLong-term patient outcomesResults Fourteen patientsLong-term outcomesPostoperative MRI studiesSurgical tumor samplesFree cortisol levelsPreoperative MRI studiesPrecise tumor localizationACTH antibodiesPituitary microCorticosteroid therapyStudy patientsDisease remissionFourteen patientsRemission rateRetrospective reviewTreatment failureCure rate
2004
Long-term outcome after epilepsy surgery for focal cortical dysplasia.
Cohen-Gadol AA, Ozduman K, Bronen RA, Kim JH, Spencer DD. Long-term outcome after epilepsy surgery for focal cortical dysplasia. Journal Of Neurosurgery 2004, 101: 55-65. PMID: 15255252, DOI: 10.3171/jns.2004.101.1.0055.Peer-Reviewed Original ResearchConceptsFocal cortical dysplasiaImproved seizure outcomeLong-term outcomesCortical dysplasiaClear marginsEpileptogenic zoneSeizure outcomeMean ageMean durationRisk factorsCortical developmentIntracranial monitoringObvious risk factorsRare disabling seizuresTransient sensorimotor deficitsMultiple subpial transectionsSubgroup of patientsExtent of resectionVisual field defectsInclusion of patientsNormal functional anatomyReports of outcomesMagnetic resonance imagingFunctional MR imagingPartial lesionectomyAnatomic dissection tractography: a new method for precise MR localization of white matter tracts.
Kier EL, Staib LH, Davis LM, Bronen RA. Anatomic dissection tractography: a new method for precise MR localization of white matter tracts. American Journal Of Neuroradiology 2004, 25: 670-6. PMID: 15140704, PMCID: PMC7974503.Peer-Reviewed Original Research
2003
Basal Ganglia Volumes in Patients With Gilles de la Tourette Syndrome
Peterson BS, Thomas P, Kane MJ, Scahill L, Zhang H, Bronen R, King RA, Leckman JF, Staib L. Basal Ganglia Volumes in Patients With Gilles de la Tourette Syndrome. JAMA Psychiatry 2003, 60: 415-424. PMID: 12695320, DOI: 10.1001/archpsyc.60.4.415.Peer-Reviewed Original ResearchConceptsBasal ganglia volumesBasal gangliaCaudate nucleus volumeTourette syndromeGanglia volumesObsessive-compulsive disorderLenticular nucleus volumesTic symptomsNucleus volumeGilles dePathophysiology of TSPrior neuroleptic exposureHealthy control subjectsSeverity of ticsComorbid obsessive-compulsive disorderGreat clinical relevanceAttention-deficit/hyperactivity disorder (ADHD) symptomsHyperactivity disorder symptomsRepeated-measures analysisNeuroleptic exposureControl subjectsFunctional disturbancesTrait abnormalityClinical relevanceGanglia
2002
Childhood Trauma Associated With Smaller Hippocampal Volume in Women With Major Depression
Vythilingam M, Heim C, Newport J, Miller AH, Anderson E, Bronen R, Brummer M, Staib L, Vermetten E, Charney DS, Nemeroff CB, Bremner JD. Childhood Trauma Associated With Smaller Hippocampal Volume in Women With Major Depression. American Journal Of Psychiatry 2002, 159: 2072-2080. PMID: 12450959, PMCID: PMC3230324, DOI: 10.1176/appi.ajp.159.12.2072.Peer-Reviewed Original ResearchConceptsSmaller hippocampal volumesMajor depressive disorderHippocampal volumeDepressive disorderDepressed subjectsDepressed womenHealthy subjectsChildhood abuseUnipolar major depressive disorderRight hippocampal volumeCoronal MRI scansAdrenal axisDepressed patientsMajor depressionControl brain regionsTemporal lobeWhole hippocampusComparison subjectsMRI scansTrauma AssociatedEarly childhood traumaFemale volunteersWhole brainBrain regionsStudy participants
2000
Choroid plexus changes after temporal lobectomy.
Saluja S, Sato N, Kawamura Y, Coughlin W, Putman C, Spencer D, Sze G, Bronen R. Choroid plexus changes after temporal lobectomy. American Journal Of Neuroradiology 2000, 21: 1650-3. PMID: 11039344, PMCID: PMC8174865.Peer-Reviewed Original ResearchConceptsTemporal lobectomyChoroid plexusPostoperative changesResection siteNormal postoperative changesRecurrent brain tumorsContrast-enhanced T1-weighted imagesPresence of infectionContrast-enhanced MR imagingDegree of enhancementT1-weighted imagesChoroid plexus changesHippocampal sclerosisRecurrent tumorsIntractable epilepsyNodular patternPathologic changesPostoperative siteLobectomyBrain tumorsEnhancement patternSurgical manipulationPlexusMorphologic changesMR imagingEffects of cell volume fraction changes on apparent diffusion in human cells
Anderson A, Xie J, Pizzonia J, Bronen R, Spencer D, Gore J. Effects of cell volume fraction changes on apparent diffusion in human cells. Magnetic Resonance Imaging 2000, 18: 689-695. PMID: 10930778, DOI: 10.1016/s0730-725x(00)00147-8.Peer-Reviewed Original ResearchCerebrospinal Fluid Cleft with Cortical Dimple: MR Imaging Marker for Focal Cortical Dysgenesis
Bronen RA, Spencer DD, Fulbright RK. Cerebrospinal Fluid Cleft with Cortical Dimple: MR Imaging Marker for Focal Cortical Dysgenesis. Radiology 2000, 214: 657-63. PMID: 10715026, DOI: 10.1148/radiology.214.3.r00mr40657.Peer-Reviewed Original ResearchMR Imaging and Histologic Features of Subinsular Bright Spots on T2-weighted MR Images: Virchow-Robin Spaces of the Extreme Capsule and Insular Cortex
Song C, Kim J, Kier E, Bronen R. MR Imaging and Histologic Features of Subinsular Bright Spots on T2-weighted MR Images: Virchow-Robin Spaces of the Extreme Capsule and Insular Cortex. Radiology 2000, 214: 671-677. PMID: 10715028, DOI: 10.1148/radiology.214.3.r00mr17671.Peer-Reviewed Original ResearchConceptsInsular cortexExtreme capsuleMR imagingControl subjectsBrain specimensPerivascular spacesFormalin-fixed brain specimensFluid-attenuated inversion recovery sequencesVirchow-Robin spacesT2-weighted magnetic resonance imagesCoronal T2-weighted imagesT2-weighted imagesCoronal MR imagesHigh signal intensityT2-weighted MR imagesInversion recovery sequenceHistologic featuresHistologic findingsCerebrospinal fluidMR imagesPatientsWhite matterPathologic conditionsGross anatomic inspectionMagnetic resonance images
1998
Surgical outcome in occipital lobe epilepsy: Implications for pathophysiology
Aykut‐Bingol C, Bronen R, Kim J, Spencer D, Spencer S. Surgical outcome in occipital lobe epilepsy: Implications for pathophysiology. Annals Of Neurology 1998, 44: 60-69. PMID: 9667593, DOI: 10.1002/ana.410440112.Peer-Reviewed Original ResearchConceptsOccipital lobe epilepsyClinical seizure characteristicsFocal cortical dysplasiaLobe epilepsyLobe locationPathological substrateSeizure characteristicsSurgical outcomesCortical dysplasiaSurgical approachSurgical proceduresRefractory occipital lobe epilepsyDevelopmental abnormalitiesOccipital lobe seizuresChronic inflammatory changesSturge-Weber syndromeMain pathological substrateOccipital lobe tumorElectroclinical variablesElectroclinical featuresMost patientsSeizure controlChronic epilepsyInflammatory changesLobe tumors
1997
Qualitative MR imaging of refractory temporal lobe epilepsy requiring surgery: correlation with pathology and seizure outcome after surgery.
Bronen RA, Fulbright RK, King D, Kim JH, Spencer SS, Spencer DD, Lange RC. Qualitative MR imaging of refractory temporal lobe epilepsy requiring surgery: correlation with pathology and seizure outcome after surgery. American Journal Of Roentgenology 1997, 169: 875-82. PMID: 9275915, DOI: 10.2214/ajr.169.3.9275915.Peer-Reviewed Original ResearchConceptsFebrile seizure historyTemporal lobe epilepsyRefractory temporal lobe epilepsyHippocampal sclerosisSeizure historySeizure outcomeLobe epilepsyHistologic findingsNonspecific gliosisHippocampal atrophyIntractable temporal lobe epilepsyMild hippocampal atrophySimilar clinical conditionsMR imaging diagnosisPositive predictive valueMR imagesSignal intensity changesSegmental findingsNormal findingsClinical parametersNeuronal densityRetrospective studyClinical conditionsSclerosisSurgeryPostoperative changes in the brain: MR imaging findings in patients without neoplasms.
Sato N, Bronen R, Sze G, Kawamura Y, Coughlin W, Putman C, Spencer D. Postoperative changes in the brain: MR imaging findings in patients without neoplasms. Radiology 1997, 204: 839-46. PMID: 9280269, DOI: 10.1148/radiology.204.3.9280269.Peer-Reviewed Original ResearchConceptsPostoperative MR imagesPostoperative changesDural enhancementEnhancement patternThin linear enhancementContrast enhancement patternMagnetic resonance imagingMR imagesSurgical marginsTemporal lobectomyNeoplastic changesExtraaxial fluidIntracranial airContrast material-enhanced MR imagesDay 5Day 51Day 30Resonance imagingSurgeryBrainPatientsTime courseContrast enhancementLinear enhancementDaysA systematic approach for interpreting MR images of the seizure patient.
Bronen RA, Fulbright RK, Kim JH, Spencer SS, Spencer DD. A systematic approach for interpreting MR images of the seizure patient. American Journal Of Roentgenology 1997, 169: 241-7. PMID: 9207533, DOI: 10.2214/ajr.169.1.9207533.Peer-Reviewed Original ResearchConceptsSubtle cortical abnormalitiesFalse-negative diagnosesHippocampal sclerosisAbnormal findingsEpileptogenic lesionsCortical thickeningSeizure patientsCortical abnormalitiesLateral ventriclePeriventricular regionEpilepsy patientsMR findingsHigh indexMorphologic abnormalitiesPeriventricular heterotopiaDual abnormalitiesGray matterDevelopmental anomaliesAbnormalitiesMR scansCortical processesMass effectHead rotationPatientsHippocampusPredicting Reading Performance From Neuroimaging Profiles: The Cerebral Basis of Phonological Effects in Printed Word Identification
Pugh K, Shaywitz B, Shaywitz S, Shankweiler D, Katz L, Fletcher J, Skudlarski P, Fulbright R, Constable R, Bronen R, Lacadie C, Gore J. Predicting Reading Performance From Neuroimaging Profiles: The Cerebral Basis of Phonological Effects in Printed Word Identification. Journal Of Experimental Psychology Human Perception & Performance 1997, 23: 299-318. PMID: 9103996, DOI: 10.1037/0096-1523.23.2.299.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingPhonological effectsLexical decision taskLexical decision latenciesLexical-semantic processesBrain activation patternsWord identificationWord recognitionDecision taskDecision latenciesRegularity effectIndividual differencesFMRI measuresHemispheric lateralizationCerebral basisExperimental paradigmActivation patternsCortical regionsLength effectYoung adultsTaskParticipantsReadingMeasuresMagnetic resonance imagingEmbryology of the human fetal hippocampus: MR imaging, anatomy, and histology.
Kier EL, Kim JH, Fulbright RK, Bronen RA. Embryology of the human fetal hippocampus: MR imaging, anatomy, and histology. American Journal Of Neuroradiology 1997, 18: 525-32. PMID: 9090416, PMCID: PMC8338418.Peer-Reviewed Original ResearchConceptsDentate gyrusCornu ammonisHippocampal sulcusGestational ageMR imagingTemporal lobeCA1-3 fieldsWeeks gestational ageHuman fetal hippocampusHuman fetal specimensWeeks' gestationAdult hippocampusFetal hippocampusCA4 fieldsCA3 fieldParahippocampal gyrusHippocampusHistologic sectionsGyrusAmmonisHippocampal anatomyFetal specimensSimilar ageMedial surfaceSulcusFocal cortical dysplasia of Taylor, balloon cell subtype: MR differentiation from low-grade tumors.
Bronen RA, Vives KP, Kim JH, Fulbright RK, Spencer SS, Spencer DD. Focal cortical dysplasia of Taylor, balloon cell subtype: MR differentiation from low-grade tumors. American Journal Of Neuroradiology 1997, 18: 1141-51. PMID: 9194442, PMCID: PMC8337292.Peer-Reviewed Original ResearchConceptsFocal cortical dysplasiaLow-grade tumorsCortical dysplasiaMR findingsLobe locationLow-grade glial neoplasmTemporal lobe locationSubcortical white matterFrontal lobe locationSurgical resectionCortical thickeningClinical variablesIntractable epilepsyGlial neoplasmsHyperintense signalLateral ventricleMR featuresWhite matterNeoplastic tissueCell subtypesDysplasiaPatientsMR variablesNeoplasmsSurgical planningEconomic impact of replacing CT with MR imaging for refractory epilepsy
Bronen R, Fulbright R, Spencer S, Spencer D, Kim J, Lange R. Economic impact of replacing CT with MR imaging for refractory epilepsy. Magnetic Resonance Imaging 1997, 15: 857-862. PMID: 9309616, DOI: 10.1016/s0730-725x(97)00047-7.Peer-Reviewed Original ResearchConceptsPreoperative evaluationRefractory epilepsyPositive imaging findingsRefractory epilepsy patientsPositive magnetic resonanceMagnetic resonanceIntracranial electroencephalogram monitoringSurgical ameliorationNormal CTImaging findingsPreoperative localizationIntractable epilepsyVascular lesionsEpileptogenic zoneElectroencephalogram monitoringPreoperative CTEpilepsy patientsPatientsMR imagingEpilepsyCTVascular substratesHealth costsLesionsSurgeryMagnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse—a preliminary report
Bremner J, Randall P, Vermetten E, Staib L, Bronen R, Mazure C, Capelli S, McCarthy G, Innis R, Charney D. Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse—a preliminary report. Biological Psychiatry 1997, 41: 23-32. PMID: 8988792, PMCID: PMC3229101, DOI: 10.1016/s0006-3223(96)00162-x.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderLeft hippocampal volumeHippocampal volumeChildhood abuseAdult survivorsSmaller left hippocampal volumeAbuse-related posttraumatic stress disorderStress disorderSmaller hippocampal volumesCombat-related posttraumatic stress disorderMagnetic resonance imagingShort-term memoryHealthy subjectsYears of educationAlcohol abuseMagnetic resonance imaging-based measurementsComparison subjectsPTSD patientsImaging-based measurementsResonance imagingPatientsSexual abusePreliminary reportSurvivorsComparison region
1996
Refractory epilepsy: comparison of MR imaging, CT, and histopathologic findings in 117 patients.
Bronen RA, Fulbright RK, Spencer DD, Spencer SS, Kim JH, Lange RC, Sutilla C. Refractory epilepsy: comparison of MR imaging, CT, and histopathologic findings in 117 patients. Radiology 1996, 201: 97-105. PMID: 8816528, DOI: 10.1148/radiology.201.1.8816528.Peer-Reviewed Original Research