2024
MULTIMODALITY IMAGING GUIDED INTRAMYOCARDIAL DELIVERY OF IMAGEABLE HYDROGEL POST MYOCARDIAL INFARCTION IMPROVES STRAIN ASSOCIATED WITH INTEGRIN ACTIVATION
Melvinsdottir I, Midgett D, Lee S, Chen K, Avendano R, Ahn S, Thorn S, Uman S, Sinusas A. MULTIMODALITY IMAGING GUIDED INTRAMYOCARDIAL DELIVERY OF IMAGEABLE HYDROGEL POST MYOCARDIAL INFARCTION IMPROVES STRAIN ASSOCIATED WITH INTEGRIN ACTIVATION. Journal Of The American College Of Cardiology 2024, 83: 1399. DOI: 10.1016/s0735-1097(24)03389-8.Peer-Reviewed Original Research
2023
Improvement in cardiac function and regional LV strain following intramyocardial injection of a theranostic hydrogel early postmyocardial infarction in a porcine model
Avendaño R, Midgett D, Melvinsdottir I, Thorn S, Uman S, Pickell Z, Lee S, Liu Z, Mamarian M, Duncan J, Spinale F, Burdick J, Sinusas A. Improvement in cardiac function and regional LV strain following intramyocardial injection of a theranostic hydrogel early postmyocardial infarction in a porcine model. Journal Of Applied Physiology 2023, 135: 405-420. PMID: 37318987, PMCID: PMC10538987, DOI: 10.1152/japplphysiol.00342.2022.Peer-Reviewed Original ResearchConceptsMyocardial infarctionIntramyocardial deliveryLV hemodynamicsControl groupFunctional indexEarly post-myocardial infarctionSystolic functional indicesMyocardial performance indexAnterolateral myocardial infarctionLeft anterior descendingPressure-volume loop areaLeft ventricular remodelingGlobal LV functionLV functional changesPost-myocardial infarctionSupply/demand ratioRegional LV strainHydrogel groupTei indexEjection fractionHeart failureAnterior descendingCircumflex arteryLV functionAortic pressure
2022
Quantification of intramyocardial blood volume using 99mTc-RBC SPECT/CT: a pilot human study
Yousefi H, Shi L, Soufer A, Tsatkin V, Bruni W, Avendano R, Greco K, McMahon D, Thorn S, Miller E, Sinusas A, Liu C. Quantification of intramyocardial blood volume using 99mTc-RBC SPECT/CT: a pilot human study. Journal Of Nuclear Cardiology 2022, 30: 292-297. PMID: 36319815, DOI: 10.1007/s12350-022-03123-0.Peer-Reviewed Original ResearchAround and Around…A Wide Complex Tachycardia
Avendaño R, Lavi N, Rosenfeld LE. Around and Around…A Wide Complex Tachycardia. Circulation 2022, 145: 1867-1869. PMID: 35728056, DOI: 10.1161/circulationaha.122.060648.Peer-Reviewed Original ResearchCineCT platform for in vivo and ex vivo measurement of 3D high resolution Lagrangian strains in the left ventricle following myocardial infarction and intramyocardial delivery of theranostic hydrogel
Midgett D, Thorn S, Ahn S, Uman S, Avendano R, Melvinsdottir I, Lysyy T, Kim J, Duncan J, Humphrey J, Papademetris X, Burdick J, Sinusas A. CineCT platform for in vivo and ex vivo measurement of 3D high resolution Lagrangian strains in the left ventricle following myocardial infarction and intramyocardial delivery of theranostic hydrogel. Journal Of Molecular And Cellular Cardiology 2022, 166: 74-90. PMID: 35227737, PMCID: PMC9035115, DOI: 10.1016/j.yjmcc.2022.02.004.Peer-Reviewed Original Research
2021
Novel SPECT and PET Tracers and Myocardial Imaging
Melvinsdottir I, Avendaño R, Sinusas A. Novel SPECT and PET Tracers and Myocardial Imaging. 2021, 189-228. DOI: 10.1007/978-3-030-83167-7_11.Peer-Reviewed Original ResearchPositron emission tomographyPET imagingMultimodality cardiovascular imagingSingle photon emissionRisk stratificationPathophysiological changesCardiac functionMyocardial remodelingMyocardial diseaseAutonomic regulationMyocardial imagingEmission tomographyHigh-resolution anatomicalMyocardial flowCardiovascular imagingPET tracersNovel SPECTMolecular changesSPECTPhoton emissionHybrid imaging technologyCell deathVivo detectionMolecular imagingImagingEffect of Hydroxychloroquine on QTc in Patients Diagnosed with COVID-19: A Systematic Review and Meta-Analysis
Arfaras-Melainis A, Tzoumas A, Kokkinidis D, Guerrero M, Varrias D, Xu X, Cerna L, Avendano R, Kemal C, Palaiodimos L, Faillace R. Effect of Hydroxychloroquine on QTc in Patients Diagnosed with COVID-19: A Systematic Review and Meta-Analysis. Journal Of Cardiovascular Development And Disease 2021, 8: 55. PMID: 34068104, PMCID: PMC8152730, DOI: 10.3390/jcdd8050055.Peer-Reviewed Original ResearchSARS-CoV-2 infectionUse of hydroxychloroquineAddition of azithromycinEffect of hydroxychloroquineSystematic reviewQTc prolongationQTc intervalManagement of patientsNumber of patientsCOVID-19Random-effects modelMedRxiv databasesCombination therapyConcomitant useInclusion criteriaHydroxychloroquinePatientsI-squarePrespecified endpointsAzithromycinQTcMeta-AnalysisInfectionSignificant increaseΔQTc
2020
Anger recall mental stress decreases 123I-metaiodobenzylguanidine (123I-MIBG) uptake and increases heterogeneity of cardiac sympathetic activity in the myocardium in patients with ischemic cardiomyopathy
Avendaño R, Hashemi-Zonouz T, Sandoval V, Liu C, Burg M, Sinusas AJ, Lampert R, Liu YH. Anger recall mental stress decreases 123I-metaiodobenzylguanidine (123I-MIBG) uptake and increases heterogeneity of cardiac sympathetic activity in the myocardium in patients with ischemic cardiomyopathy. Journal Of Nuclear Cardiology 2020, 29: 798-809. PMID: 33034036, DOI: 10.1007/s12350-020-02372-1.Peer-Reviewed Original ResearchConceptsSympathetic activityIschemic cardiomyopathyVentricular arrhythmiasICM patientsMental stressAge-matched healthy male controlsCardiac sympathetic activityHealthy control subjectsMyocardial sympathetic activityHealthy male controlsMental stress taskSPECT/CTMediastinal ratioControl subjectsHemodynamic responseAnger recallMyocardial perfusionNormal subjectsMale controlsPatientsPerfusionPsychological stressorsArrhythmiasStress taskDual-isotope imagingApplication Of Cine CT Imaging For Evaluation Of Biomechanics Of The Left Ventricle Post Myocardial Infarction And Following Intramyocardial Delivery Of Imageable Hydrogel
Midgett D, Sinusas A, Melvinsdottir I, Avendano R, Lee S. Application Of Cine CT Imaging For Evaluation Of Biomechanics Of The Left Ventricle Post Myocardial Infarction And Following Intramyocardial Delivery Of Imageable Hydrogel. Journal Of Cardiovascular Computed Tomography 2020, 14: s28-s29. DOI: 10.1016/j.jcct.2020.06.035.Peer-Reviewed Original ResearchChapter 1 Embryology, Anatomy, and Physiology Anatomical Variations, Lipomatous Hypertrophy, Atrial Septal Aneurysm, Eustachian Valve, Chiari Network, Combination With Other Atrial Septal Defects
Kokkinidis D, Rios S, Avendano R, Zaidi A, Faillace R. Chapter 1 Embryology, Anatomy, and Physiology Anatomical Variations, Lipomatous Hypertrophy, Atrial Septal Aneurysm, Eustachian Valve, Chiari Network, Combination With Other Atrial Septal Defects. 2020, 3-12. DOI: 10.1016/b978-0-12-816966-7.00001-4.Peer-Reviewed Original ResearchPatent foramen ovaleAtrial septal aneurysmSeptal aneurysmPercutaneous closureEustachian valveInteratrial septumChiari networkSerious clinical syndromeAtrial septal defectCongenital cardiac malformationsParadoxical systemic embolismSystemic embolismIschemic strokeProfound hypoxemiaLipomatous hypertrophyForamen ovaleAnatomic anomaliesClinical syndromeInteratrial communicationMyocardial infarctionSeptal defectRisk factorsClinical impactMigraine headacheCardiac malformations
2019
Mastering the art of epicardial access in cardiac electrophysiology
Romero J, Shivkumar K, Di Biase L, Avendano R, Anderson R, Natale A, Kumar S. Mastering the art of epicardial access in cardiac electrophysiology. Heart Rhythm 2019, 16: 1738-1749. PMID: 31015022, DOI: 10.1016/j.hrthm.2019.04.038.Peer-Reviewed Original ResearchConceptsVentricular arrhythmiasEpicardial accessEpicardial spaceRight ventricular perforationAtrial appendage occlusionAtrial fibrillation proceduresRight atrial appendageCardiac magnetic resonanceEpicardial pacing leadsVentricular perforationCoronary sinusAppendage occlusionCatheter ablationEsophageal protectionCardiac proceduresAccessory pathwayAtrial appendageNerve displacementTraditional indicationsPacing leadsSafe ablationCardiac anatomyNovel indicationsMultiple technological advancesAccess successBrugada Syndrome: Progress in Genetics, Risk Stratification and Management
Romero J, Li DL, Avendano R, Diaz JC, Tung R, Di Biase L. Brugada Syndrome: Progress in Genetics, Risk Stratification and Management. Arrhythmia & Electrophysiology Review 2019, 8: 19-27. PMID: 30918663, PMCID: PMC6434506, DOI: 10.15420/aer.2018.66.2.Peer-Reviewed Original ResearchNON-FLUOROSCOPIC CATHETER ABLATION OF PVC: RESULTS FROM A MULTICENTER STUDY
Avendano R, Cerna L, Di Biase L, Horton R, Mohanty S, Trivedi C, Natale A, Romero J. NON-FLUOROSCOPIC CATHETER ABLATION OF PVC: RESULTS FROM A MULTICENTER STUDY. Journal Of The American College Of Cardiology 2019, 73: 336. DOI: 10.1016/s0735-1097(19)30944-1.Peer-Reviewed Original Research
2018
Is it safe to stop oral anticoagulation after catheter ablation for atrial fibrillation?
Romero J, Avendano R, Diaz J, Taveras J, Lupercio F, Di Biase L. Is it safe to stop oral anticoagulation after catheter ablation for atrial fibrillation? Expert Review Of Cardiovascular Therapy 2018, 17: 31-41. PMID: 30460874, DOI: 10.1080/14779072.2019.1550718.Peer-Reviewed Original ResearchConceptsCatheter ablationAtrial fibrillationOral anticoagulantsOral anticoagulationBlanking periodRisk of bleedingSociety guidelinesCommon arrhythmiaCurrent guidelinesFibrillationAnticoagulantsRelevant articlesMajor databasesAnticoagulationAblationRiskGuidelinesBleedingEMBASEArrhythmiasPubMedStrokeMajor recommendationsPrevalenceBivalirudin versus heparin in patients undergoing percutaneous peripheral interventions: A systematic review and meta-analysis
Olmedo W, Villablanca P, Sanina C, Walker J, Weinreich M, Brevik J, Avendano R, Bravo C, Romero J, Ramakrishna H, Babaev A, Attubato M, Hernandez-Suarez D, Cox-Alomar P, Pyo R, Krishnan P, Wiley J. Bivalirudin versus heparin in patients undergoing percutaneous peripheral interventions: A systematic review and meta-analysis. Vascular 2018, 27: 78-89. PMID: 30501582, DOI: 10.1177/1708538118807522.Peer-Reviewed Original ResearchConceptsPercutaneous peripheral interventionsAccess site complicationsPeripheral interventionsCause mortalitySite complicationsMinor bleedingSystematic reviewEfficacy of bivalirudinProcedural anticoagulant agentLarge randomized trialsSignificant differencesBivalirudin useMajor bleedingIntracranial bleedingBlood transfusionRandomized trialsMyocardial infarctionAnticoagulant agentsClinical studiesBivalirudinBleedingComplicationsPatientsHeparinMortalityCombined Endocardial-Epicardial Versus Endocardial Catheter Ablation Alone for Ventricular Tachycardia in Structural Heart Disease A Systematic Review and Meta-Analysis
Romero J, Cerrud-Rodriguez R, Di Biase L, Diaz J, Alviz I, Grupposo V, Cerna L, Avendano R, Tedrow U, Natale A, Tung R, Kumar S. Combined Endocardial-Epicardial Versus Endocardial Catheter Ablation Alone for Ventricular Tachycardia in Structural Heart Disease A Systematic Review and Meta-Analysis. JACC Clinical Electrophysiology 2018, 5: 13-24. PMID: 30678778, DOI: 10.1016/j.jacep.2018.08.010.Peer-Reviewed Original ResearchConceptsArrhythmogenic right ventricular cardiomyopathyVentricular tachycardiaNonischemic cardiomyopathyIschemic cardiomyopathyProcedural complicationsVT recurrenceEndocardial ablationVT ablationLower riskSystematic reviewLimited single-center studyEndocardial catheter ablationSingle-center studyAcute procedural complicationsA Systematic ReviewRight ventricular cardiomyopathyCause mortalityCatheter ablationEmbase databasesVentricular cardiomyopathyAblation strategyNonsignificant trendSubsequent mortalityPatientsMeta-AnalysisClinical outcomes in patients with atrial fibrillation receiving amiodarone on NOACs vs. warfarin
Avendano R, Romero J, Lupercio F, Diaz J, Quispe R, Golive A, Natale A, Garcia M, Krumerman A, Di Biase L. Clinical outcomes in patients with atrial fibrillation receiving amiodarone on NOACs vs. warfarin. Journal Of Interventional Cardiac Electrophysiology 2018, 54: 73-80. PMID: 30128801, DOI: 10.1007/s10840-018-0427-y.Peer-Reviewed Original ResearchConceptsNew oral anticoagulantsMajor bleedingAtrial fibrillationThromboembolic eventsIntracranial bleedingClinical outcomesRisk ratioStroke/thromboembolic eventsRecent retrospective trialsMantel-Haenszel methodConclusionAmong patientsTE preventionOral anticoagulantsIncreased riskRetrospective trialsResultsA totalHigh riskAmiodaroneBleedingPatientsWarfarinSystematic reviewP-glycoproteinConfidence intervalsOutcomesPrevention of sudden cardiac death in ischaemic cardiomyopathy
Romero J, Natale A, Avendano R, Garcia M, Biase L. Prevention of sudden cardiac death in ischaemic cardiomyopathy. 2018, 2333-2337. DOI: 10.1093/med/9780198784906.003.0552.Peer-Reviewed Original ResearchLeft ventricular ejection fractionSudden cardiac deathAcute myocardial infarctionRisk stratificationMyocardial infarctionElectrophysiological studiesCardiac deathIschemic cardiomyopathyPrevention of SCDCardiac iodine-123 metaiodobenzylguanidineIodine-123 metaiodobenzylguanidineTransient myocardial stunningCardiovascular magnetic resonance imagingVentricular ejection fractionPrimary prevention strategiesMajor health problemChronic myocardial infarctionImplantable cardioverter defibrillatorMagnetic resonance imagingEjection fractionVentricular arrhythmiasLVEF assessmentPrimary preventionMyocardial stunningCurrent guidelinesUninterrupted direct oral anticoagulants vs. uninterrupted vitamin K antagonists during catheter ablation of non-valvular atrial fibrillation: a systematic review and meta-analysis of randomized controlled trials
Romero J, Cerrud-Rodriguez R, Diaz J, Michaud G, Taveras J, Alviz I, Grupposo V, Cerna L, Avendano R, Kumar S, Kirchhof P, Natale A, Di Biase L. Uninterrupted direct oral anticoagulants vs. uninterrupted vitamin K antagonists during catheter ablation of non-valvular atrial fibrillation: a systematic review and meta-analysis of randomized controlled trials. EP Europace 2018, 20: 1612-1620. PMID: 29982383, DOI: 10.1093/europace/euy133.Peer-Reviewed Original ResearchConceptsNon-valvular atrial fibrillationUninterrupted direct oral anticoagulantsUninterrupted vitamin K antagonistsDirect oral anticoagulantsVitamin K antagonistsMajor bleeding eventsSilent cerebral infarctionThrombo-embolic eventsCatheter ablationBleeding eventsAtrial fibrillationMajor bleedingK antagonistsOral anticoagulantsSystematic reviewBrain magnetic resonance imagingMinor bleeding eventsFirst-line therapyParoxysmal atrial fibrillationRandom-effects modelMagnetic resonance imagingFixed-effects modelMinor bleedingCerebral infarctionLine therapyEarly Versus Late Referral for Catheter Ablation of Ventricular Tachycardia in Patients With Structural Heart Disease A Systematic Review and Meta-Analysis of Clinical Outcomes
Romero J, Di Biase L, Diaz J, Quispe R, Du X, Briceno D, Avendano R, Tedrow U, John R, Michaud G, Natale A, Stevenson W, Kumar S. Early Versus Late Referral for Catheter Ablation of Ventricular Tachycardia in Patients With Structural Heart Disease A Systematic Review and Meta-Analysis of Clinical Outcomes. JACC Clinical Electrophysiology 2018, 4: 374-382. PMID: 30089564, DOI: 10.1016/j.jacep.2017.12.008.Peer-Reviewed Original ResearchConceptsStructural heart diseaseEarly referralLate referralVT ablationVentricular tachycardiaAcute complicationsVT recurrenceCatheter ablationHeart diseaseTotal mortalityLong-term VT recurrenceAcute procedural successA Systematic ReviewAcute successSecondary outcomesPrimary outcomeAntiarrhythmic drugsClinical outcomesProcedural successPatient populationWorse outcomesBetter outcomesElectronic searchPatientsReferral