Effect of Hydroxychloroquine on QTc in Patients Diagnosed with COVID-19: A Systematic Review and Meta-Analysis
Arfaras-Melainis A, Tzoumas A, Kokkinidis D, Guerrero M, Varrias D, Xu X, Cerna L, Avendano R, Kemal C, Palaiodimos L, Faillace R. Effect of Hydroxychloroquine on QTc in Patients Diagnosed with COVID-19: A Systematic Review and Meta-Analysis. Journal Of Cardiovascular Development And Disease 2021, 8: 55. PMID: 34068104, PMCID: PMC8152730, DOI: 10.3390/jcdd8050055.Peer-Reviewed Original ResearchSARS-CoV-2 infectionUse of hydroxychloroquineAddition of azithromycinEffect of hydroxychloroquineSystematic reviewQTc prolongationQTc intervalManagement of patientsNumber of patientsCOVID-19Random-effects modelMedRxiv databasesCombination therapyConcomitant useInclusion criteriaHydroxychloroquinePatientsI-squarePrespecified endpointsAzithromycinQTcMeta-AnalysisInfectionSignificant increaseΔQTc