2023
Polysubstance addiction patterns among 7,989 individuals with cocaine use disorder
Stiltner B, Pietrzak R, Tylee D, Nunez Y, Adhikari K, Kranzler H, Gelernter J, Polimanti R. Polysubstance addiction patterns among 7,989 individuals with cocaine use disorder. IScience 2023, 26: 107336. PMID: 37554454, PMCID: PMC10405253, DOI: 10.1016/j.isci.2023.107336.Peer-Reviewed Original ResearchCocaine use disorderUse disordersAddiction patternsMixed bipolar episodesLatent class analysisDSM-5 diagnosisPosttraumatic stress disorderAntisocial personality disorderPsA severityMedication useHigher PSAPSA subgroupsHigher oddsBipolar episodesStress disorderPersonality disorderDisordersSubgroupsAgeSexClass analysisParticipantsComorbiditiesDiseaseDiagnosis
2021
Role of microbes in the pathogenesis of neuropsychiatric disorders
Goswami A, Wendt FR, Pathak GA, Tylee DS, De Angelis F, De Lillo A, Polimanti R. Role of microbes in the pathogenesis of neuropsychiatric disorders. Frontiers In Neuroendocrinology 2021, 62: 100917. PMID: 33957173, PMCID: PMC8364482, DOI: 10.1016/j.yfrne.2021.100917.Peer-Reviewed Original ResearchConceptsNeuropsychiatric disordersDifferent anatomical sitesOral cavityAnatomical sitesHuman studiesBody sitesTranslational potentialPotential involvementPathogenesisGutMicrobial metabolitesDisordersBidirectional communicationStrong evidenceDiseaseNeurotransmittersBrainMicrobiome researchMicrobiome variation
2020
Phenotypic and Molecular Characterization of Risk Loci Associated With Asthma and Lung Function
Karaca M, Atceken N, Karaca Ş, Civelek E, Şekerel BE, Polimanti R. Phenotypic and Molecular Characterization of Risk Loci Associated With Asthma and Lung Function. Allergy Asthma And Immunology Research 2020, 12: 806-820. PMID: 32638561, PMCID: PMC7347000, DOI: 10.4168/aair.2020.12.5.806.Peer-Reviewed Original ResearchLung functionRespiratory diseaseFat massPulmonary function testsPhenome-wide association studyAllergic respiratory diseasesBody fat massPrevious genome-wide association studyGenome-wide association studiesAsthma comorbidityAdult asthmaAsthma pathogenesisFunction testsPediatric cohortBlood levelsImmune cellsAllergic reactionsMultifactorial etiologyAsthmaAssociation studiesIndividual susceptibilityRisk allelesDiseaseDiscovery Genome-Wide Association StudiesComorbidities
2015
Explorative genetic association study of GSTT2B copy number variant in complex disease risks
Iorio A, Polimanti R, Calandro M, Graziano ME, Piacentini S, Bucossi S, Squitti R, Lazzarin N, Scano G, Limbruno GM, Manfellotto D, Fuciarelli M. Explorative genetic association study of GSTT2B copy number variant in complex disease risks. Annals Of Human Biology 2015, 43: 279-284. PMID: 26207597, DOI: 10.3109/03014460.2015.1049206.Peer-Reviewed Original ResearchConceptsOdds ratioAllergic rhinitisEssential hypertensionRecurrent miscarriageAlzheimer's diseaseCopy number variantsGlutathione S-transferaseCase-control groupPhase II enzymesStudy populationItalian patientsLarger sample sizeDisease statusDisease riskExogenous toxic compoundsPhase IPathological phenotypesDiseaseNumber variantsHealth-related phenotypesFurther investigationGenetic association studiesII enzymesComplex diseasesS-transferase
2014
Low-copper diet as a preventive strategy for Alzheimer's disease
Squitti R, Siotto M, Polimanti R. Low-copper diet as a preventive strategy for Alzheimer's disease. Neurobiology Of Aging 2014, 35: s40-s50. PMID: 24913894, DOI: 10.1016/j.neurobiolaging.2014.02.031.Peer-Reviewed Original ResearchConceptsLow copper dietAlzheimer's diseasePreventive strategiesRisk of ADSporadic Alzheimer's diseaseCopper metabolismAdverse sequelaeDietary intakePathogenetic mechanismsGeneral populationAD riskPathogenic mechanismsDiseaseDietCopper deficiencyRecent studiesRiskMetabolismPhenotypeSequelaeDerangementIntake
2013
Metal Dysfunction in Alzheimer’s Disease
Squitti R, Siotto M, Salustri C, Polimanti R. Metal Dysfunction in Alzheimer’s Disease. Oxidative Stress In Applied Basic Research And Clinical Practice 2013, 73-97. DOI: 10.1007/978-1-62703-598-9_7.Peer-Reviewed Original Research
2012
Association of K832R and R952K SNPs of Wilson's Disease Gene with Alzheimer's Disease
Bucossi S, Polimanti R, Mariani S, Ventriglia M, Bonvicini C, Migliore S, Manfellotto D, Salustri C, Vernieri F, Rossini PM, Squitti R. Association of K832R and R952K SNPs of Wilson's Disease Gene with Alzheimer's Disease. Journal Of Alzheimer's Disease 2012, 29: 913-919. PMID: 22356903, DOI: 10.3233/jad-2012-111997.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphatasesAgedAged, 80 and overAlzheimer DiseaseArginineCation Transport ProteinsCopper-transporting ATPasesFemaleGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHumansLinkage DisequilibriumLogistic ModelsLysineMaleMiddle AgedPolymorphism, Single NucleotideConceptsDisease patientsAD patientsApolipoprotein E ε4 allele frequencyAPOE ε4 variantΕ4 allele frequencyAlzheimer's disease patientsATP7B geneLocus of susceptibilityΕ4 variantHealthy controlsNeurodegenerative processesAlzheimer's diseasePatientsRisk allelesDiseaseCopper dysfunctionR alleleATP7B allelesWilson disease geneK alleleDisease genesGSTM1 null genotype as risk factor for late-onset Alzheimer's disease in Italian patients
Piacentini S, Polimanti R, Squitti R, Ventriglia M, Cassetta E, Vernieri F, Rossini PM, Manfellotto D, Fuciarelli M. GSTM1 null genotype as risk factor for late-onset Alzheimer's disease in Italian patients. Journal Of The Neurological Sciences 2012, 317: 137-140. PMID: 22381228, DOI: 10.1016/j.jns.2012.01.026.Peer-Reviewed Original ResearchConceptsGSTM1 null genotypeAlzheimer's diseaseNull genotypeRisk factorsItalian patientsCause of ADLate-onset Alzheimer's diseaseLogistic regression analysisGlutathione S-transferaseCase-control populationAD patientsAD riskGSTM1 geneGSTT1 genesGenotype distributionDisease riskNeurodegenerative disordersDiseasePatientsOxidative stressEndogenous metabolitesCommon formRegression analysisPositive associationGSTM1