Featured Publications
An Atlas of Genetic Correlations and Genetically Informed Associations Linking Psychiatric and Immune-Related Phenotypes
Tylee DS, Lee YK, Wendt FR, Pathak GA, Levey DF, De Angelis F, Gelernter J, Polimanti R. An Atlas of Genetic Correlations and Genetically Informed Associations Linking Psychiatric and Immune-Related Phenotypes. JAMA Psychiatry 2022, 79: 667-676. PMID: 35507366, PMCID: PMC9069342, DOI: 10.1001/jamapsychiatry.2022.0914.Peer-Reviewed Original ResearchConceptsRisk factorsImmune-related phenotypesMultivariable adjustmentUlcerative colitisCrohn's diseaseMendelian randomizationImmune-related disordersReciprocal risk factorsHealth-related behaviorsPsychiatric phenotypesFalse discovery rate correctionAllergic rhinitisGenetic association studiesGenetic associationInflammatory disordersClinical associationsMajor depressionImmune disordersMAIN OUTCOMEPsychiatric disordersSocial determinantsDisordersAssociation studiesColitisAsthma
2020
Phenotypic and Molecular Characterization of Risk Loci Associated With Asthma and Lung Function
Karaca M, Atceken N, Karaca Ş, Civelek E, Şekerel BE, Polimanti R. Phenotypic and Molecular Characterization of Risk Loci Associated With Asthma and Lung Function. Allergy Asthma And Immunology Research 2020, 12: 806-820. PMID: 32638561, PMCID: PMC7347000, DOI: 10.4168/aair.2020.12.5.806.Peer-Reviewed Original ResearchLung functionRespiratory diseaseFat massPulmonary function testsPhenome-wide association studyAllergic respiratory diseasesBody fat massPrevious genome-wide association studyGenome-wide association studiesAsthma comorbidityAdult asthmaAsthma pathogenesisFunction testsPediatric cohortBlood levelsImmune cellsAllergic reactionsMultifactorial etiologyAsthmaAssociation studiesIndividual susceptibilityRisk allelesDiseaseDiscovery Genome-Wide Association StudiesComorbidities
2016
Allergy-specific Phenome-Wide Association Study for Immunogenes in Turkish Children
Karaca S, Civelek E, Karaca M, Sahiner UM, Ozgul RK, Kocabas CN, Polimanti R, Sekerel BE. Allergy-specific Phenome-Wide Association Study for Immunogenes in Turkish Children. Scientific Reports 2016, 6: 33152. PMID: 27624002, PMCID: PMC5021980, DOI: 10.1038/srep33152.Peer-Reviewed Original ResearchConceptsHypertonic saline challenge testTurkish childrenAllergic airway inflammationPhenome-wide association studySkin prick testRole of immunogeneticsCross-sectional studyDifferent immune functionsAllergic bronchitisCD14 rs2569190Airway inflammationAtopic marchPrick testAsthma diagnosisLung functionBlood testsIL4 rs2243250Immune functionChallenge testAssociation studiesADAM33ComorbiditiesChildrenAssociationAsthma
2012
Lack of association between GSTM1, GSTP1, and GSTT1 gene polymorphisms and asthma in adult patients from Rome, central Italy.
Piacentini S, Polimanti R, Moscatelli B, Re MA, Manfellotto D, Fuciarelli M. Lack of association between GSTM1, GSTP1, and GSTT1 gene polymorphisms and asthma in adult patients from Rome, central Italy. Journal Of Investigational Allergology And Clinical Immunology 2012, 22: 252-6. PMID: 22812193.Peer-Reviewed Original ResearchConceptsDevelopment of asthmaAsthma developmentPolymerase chain reactionGSTP1 polymorphismsGlutathione S-transferaseGene polymorphismsOxidative stressGST gene polymorphismsLack of associationGSTT1 gene polymorphismsComplex multifactorial diseasePCR-restriction fragment length polymorphism analysisAsthmatic patientsAdult patientsAsthma pathogenesisInflammatory responseAsthma riskGST polymorphismsAsthmaMultiplex polymerase chain reactionHealthy individualsAntioxidant defense systemGSTT1 genesMultifactorial diseaseUnrelated healthy individuals
2010
GSTA1, GSTO1 and GSTO2 gene polymorphisms in Italian asthma patients
Polimanti R, Piacentini S, Moscatelli B, Pellicciotti L, Manfellotto D, Fuciarelli M. GSTA1, GSTO1 and GSTO2 gene polymorphisms in Italian asthma patients. Clinical And Experimental Pharmacology And Physiology 2010, 37: 870-872. PMID: 20374258, DOI: 10.1111/j.1440-1681.2010.05385.x.Peer-Reviewed Original ResearchConceptsRisk of asthmaGSTO2 gene polymorphismsGene polymorphismsPolymerase chain reaction-restriction fragment length polymorphismReaction-restriction fragment length polymorphismTwo-pair primer (PCR-CTPP) methodGSTA1 genotypeAsthma patientsAsthmaEpidemiological studiesGlutathione S-transferase enzymesT genotypeControl groupPotential associationAsthmaticsGSTA1Primer methodGenetic alterationsGSTO2 genesFragment length polymorphismRiskPresent studyGSTO1PolymorphismAssociationGlutathione S-transferase gene polymorphisms and air pollution as interactive risk factors for asthma in a multicentre Italian field study: A preliminary study
Piacentini S, Polimanti R, Moscatelli B, Re MA, Fuciarelli R, Manfellotto D, Fuciarelli M. Glutathione S-transferase gene polymorphisms and air pollution as interactive risk factors for asthma in a multicentre Italian field study: A preliminary study. Annals Of Human Biology 2010, 37: 427-439. PMID: 20367187, DOI: 10.3109/03014461003636419.Peer-Reviewed Original ResearchConceptsGlutathione S-transferase (GST) gene polymorphismsImpairs pulmonary functionCommon chronic diseasesCase-control studyGlutathione S-transferaseGenotyping of GSTM1Interactive risk factorsFrequency of GSTA1Asthmatic patientsPulmonary functionAsthma developmentRisk factorsChronic diseasesGSTT1 genotypeGSTP1 polymorphismsPCR-RFLP methodAsthma diseaseGene-environment interactionsControl groupGene polymorphismsGSTT1 genesPossible associationReactive oxygen speciesProtection of cellsAsthma