2019
In a Free-Living Setting, Obesity Is Associated With Greater Food Intake in Response to a Similar Premeal Glucose Nadir
Kim J, Lam W, Wang Q, Parikh L, Elshafie A, Sanchez-Rangel E, Schmidt C, Li F, Hwang J, Belfort-DeAguiar R. In a Free-Living Setting, Obesity Is Associated With Greater Food Intake in Response to a Similar Premeal Glucose Nadir. The Journal Of Clinical Endocrinology & Metabolism 2019, 104: 3911-3919. PMID: 31087061, PMCID: PMC6667277, DOI: 10.1210/jc.2019-00240.Peer-Reviewed Original ResearchFood intakeGlucose levelsNW individualsOB individualsPremeal glucoseCGM glucose levelsNormal-weight individualsBlood glucose levelsContinuous glucose-monitoring systemGreater food intakeInterstitial glucose levelsGlucose-monitoring systemGlucose nadirsWeight individualsGlucose profilesObeseFood logsEffect of glucoseHealthy individualsFree-Living SettingsIntakePostprandial ratesObesityLevel stimuliPredictive effect
2011
Circulating glucose levels modulate neural control of desire for high-calorie foods in humans
Page KA, Seo D, Belfort-DeAguiar R, Lacadie C, Dzuira J, Naik S, Amarnath S, Constable RT, Sherwin RS, Sinha R. Circulating glucose levels modulate neural control of desire for high-calorie foods in humans. Journal Of Clinical Investigation 2011, 121: 4161-4169. PMID: 21926468, PMCID: PMC3195474, DOI: 10.1172/jci57873.Peer-Reviewed Original ResearchConceptsHigh-calorie foodsGlucose levelsHyperinsulinemic euglycemic-hypoglycemic clampsBrain regionsFunctional MRIMedial prefrontal cortexMedial prefrontal cortex activationRisk of overeatingLevels of glucosePostprandial reductionPrefrontal cortex activationObese subjectsNonobese individualsMild hypoglycemiaWorldwide epidemicCortex activationPrefrontal cortexFood cuesFood motivationFood stimuliNeural controlObesityInhibitory controlBehavioral measuresVisual cues