2011
A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms
Chen Y, Rai R, Zhou ZR, Kanoh J, Ribeyre C, Yang Y, Zheng H, Damay P, Wang F, Tsujii H, Hiraoka Y, Shore D, Hu HY, Chang S, Lei M. A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms. Nature Structural & Molecular Biology 2011, 18: 213-221. PMID: 21217703, PMCID: PMC3688267, DOI: 10.1038/nsmb.1974.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid MotifsAmino Acid SequenceAnimalsCells, CulturedCrystallography, X-RayFungal ProteinsHeLa CellsHumansModels, MolecularMolecular Sequence DataMutationNuclear Magnetic Resonance, BiomolecularProtein BindingProtein Interaction Domains and MotifsSaccharomycetalesSchizosaccharomycesShelterin ComplexTelomereTelomere-Binding ProteinsTelomeric Repeat Binding Protein 2ConceptsRap1 C-terminusDifferent interacting partnersProtein Rap1Fission yeastTelomere protectionInteracting partnerTranscriptional silencingDifferent organismsC-terminusFunctional analysisInteraction moduleYeastRap1Different functionsOrganismsTaz1Sir3TRF2MammalianTelomeresSilencingMammalsMotifCrystal structureRegulation
2006
BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer
Rai R, Dai H, Multani AS, Li K, Chin K, Gray J, Lahad JP, Liang J, Mills GB, Meric-Bernstam F, Lin SY. BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer. Cancer Cell 2006, 10: 145-157. PMID: 16872911, PMCID: PMC1557410, DOI: 10.1016/j.ccr.2006.07.002.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceBreast NeoplasmsCell Cycle ProteinsCell Line, TumorCell NucleusCell Transformation, NeoplasticChromatinChromosome AberrationsCytoskeletal ProteinsDNA DamageFemaleGene DosageHumansMolecular Sequence DataMutationNerve Tissue ProteinsNuclear ProteinsOvarian NeoplasmsTrans-ActivatorsTumor Suppressor ProteinsConceptsATM/ATR pathwayDNA damage response pathwayEarly DNA damage responseDNA damage regulatorDNA damage checkpointDamage response pathwayDNA damage responseTumor suppressor geneHTERT repressorDamage checkpointATR pathwayDamage responseResponse pathwaysBRIT1Chromosomal integrityGenomic instabilitySuppressor geneHuman cancersAdditional functionsChromosomal aberrationsPathwayMDC1NBS1RepressorGenes
2004
Genome wide instability scanning in chewing-tobacco associated oral cancer using inter simple sequence repeat PCR
Rai R, Kulkarni V, Saranath D. Genome wide instability scanning in chewing-tobacco associated oral cancer using inter simple sequence repeat PCR. Oral Oncology 2004, 40: 1033-1039. PMID: 15509495, DOI: 10.1016/j.oraloncology.2004.05.009.Peer-Reviewed Original ResearchConceptsOral cancerTumor tissueNormal tissuesOral cancer patientsTumor-adjacent normal tissuesOral cancer samplesAdjacent normal tissuesMultiple tumor tissuesCancer patientsNormal tissue DNATumor progressionCancer samplesGenomic instability indexCancerTissue DNAGenomic alterationsTumor heterogeneityGenomic instabilityTissueMolecular cloning, isolation and characterisation of ERK3 gene from chewing-tobacco induced oral squamous cell carcinoma
Rai R, Mahale A, Saranath D. Molecular cloning, isolation and characterisation of ERK3 gene from chewing-tobacco induced oral squamous cell carcinoma. Oral Oncology 2004, 40: 705-712. PMID: 15172640, DOI: 10.1016/j.oraloncology.2004.01.010.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceBlotting, NorthernBlotting, SouthernCarcinoma, Squamous CellCloning, MolecularDNA, ComplementaryDNA, NeoplasmGene ExpressionGene LibraryHumansMitogen-Activated Protein Kinase 6Mitogen-Activated Protein KinasesMolecular Sequence DataMouth NeoplasmsReverse Transcriptase Polymerase Chain ReactionTobacco, SmokelessConceptsOral cancer tissuesOral squamous cell carcinomaSquamous cell carcinomaPeripheral blood cellsNormal healthy individualsCancer tissuesExtracellular signal-regulated protein kinaseCell carcinomaOral cancerHealthy individualsNon-coding regionBlood cellsSerine/threonine kinaseSignal-regulated protein kinaseTobacco habitsC-Jun N-terminal kinaseFetal skeletal muscleMRNA transcript analysisNormal individualsN-terminal kinaseRegulation of mRNAPatient samplesRT-PCR analysisSkeletal muscleERK3 expression