DNA damage response: the players, the network and the role in tumor suppression.
Rai R, Peng G, Li K, Lin SY. DNA damage response: the players, the network and the role in tumor suppression. Cancer Genomics & Proteomics 2007, 4: 99-106. PMID: 17804872.Peer-Reviewed Original ResearchConceptsDNA damage responseDamage responseDNA-damaging insultsCell cycle checkpointsDNA damage lesionsGenomic integrityCycle checkpointsDNA repairGenomic instabilityTumor suppressionMolecular eventsGenetic instabilityDNA damageDamage lesionsCancer developmentNormal cellsComplex mechanismsCommon featureCheckpointTumorigenesisPathwayResponseCells