2022
Vaccination With Leptospira interrogans PF07598 Gene Family-Encoded Virulence Modifying Proteins Protects Mice From Severe Leptospirosis and Reduces Bacterial Load in the Liver and Kidney
Chaurasia R, Salovey A, Guo X, Desir G, Vinetz JM. Vaccination With Leptospira interrogans PF07598 Gene Family-Encoded Virulence Modifying Proteins Protects Mice From Severe Leptospirosis and Reduces Bacterial Load in the Liver and Kidney. Frontiers In Cellular And Infection Microbiology 2022, 12: 926994. PMID: 35837473, PMCID: PMC9274288, DOI: 10.3389/fcimb.2022.926994.Peer-Reviewed Original ResearchConceptsLethal challenge infectionChallenge infectionBacterial loadC3H/HeJ miceKey target organClinical pathogenesisSevere leptospirosisOrgan infectionProtein immunizationHeJ miceSerovar CanicolaTarget organsAnimal modelsLeptospirosis pathogenesisCellular pathogenesisMicePathogenesisInfectionLeptospira interrogansVirulence factorsModifying proteinsImmunizationKidneyLeptospirosisLiver
2018
Pathogen-specific leptospiral proteins in urine of patients with febrile illness aids in differential diagnosis of leptospirosis from dengue
Chaurasia R, Thresiamma K, Eapen C, Zachariah B, Paul R, Sritharan M. Pathogen-specific leptospiral proteins in urine of patients with febrile illness aids in differential diagnosis of leptospirosis from dengue. European Journal Of Clinical Microbiology & Infectious Diseases 2018, 37: 423-433. PMID: 29332210, DOI: 10.1007/s10096-018-3187-9.Peer-Reviewed Original ResearchConceptsMicroscopic agglutination testAnti-leptospiral antibodiesEnzyme-linked immunosorbent assayLeptospiral antigensDifferential diagnosisGroup I patientsUrine of patientsPUO patientsI patientsUrinary antigenClinical symptomsDengue patientsNon-invasive methodStudy groupPatientsHigh titresDengue feverAgglutination testUnknown originInfectious diseasesAntigenDiagnosisImmunosorbent assayUrine samplesSpecific antibodies
2015
Urban leptospirosis: A report of two cases
Sarguna P, Rao M, Sivakolundu S, Chaurasia R, Sritharan M, Shankar K. Urban leptospirosis: A report of two cases. Indian Journal Of Medical Microbiology 2015, 33: 321-323. PMID: 25865999, DOI: 10.4103/0255-0857.154898.Peer-Reviewed Original Research