2024
Computational reassessment of RNA-seq data reveals key genes in active tuberculosis
Arya R, Shakya H, Chaurasia R, Kumar S, Vinetz J, Kim J. Computational reassessment of RNA-seq data reveals key genes in active tuberculosis. PLOS ONE 2024, 19: e0305582. PMID: 38935691, PMCID: PMC11210783, DOI: 10.1371/journal.pone.0305582.Peer-Reviewed Original ResearchConceptsMolecular Complex DetectionProtein-protein interactionsDeregulated genesGene OntologyRNA-seq dataGene Expression Omnibus (GEO) databaseIncreasing prevalence of multidrug-resistantGEO2R online toolPrevalence of multidrug resistancePathway enrichment analysisExpression levelsPatterns of variationGene expression levelsArea under curveInnate immune responseGene networksCore genesMicroarray datasetsSTRING databaseTranscript levelsEnrichment analysisGenesInterferon signalingInterferon-gamma signalingResponse to Mtb infectionExploring the Role of Extracellular Vesicles in the Pathogenesis of Tuberculosis
Arya R, Shakya H, Chaurasia R, Haque A, Kim J. Exploring the Role of Extracellular Vesicles in the Pathogenesis of Tuberculosis. Genes 2024, 15: 434. PMID: 38674369, PMCID: PMC11049626, DOI: 10.3390/genes15040434.Peer-Reviewed Original ResearchConceptsProtein-protein interaction networkRNA-seq datasetsExtracellular vesiclesTB patientsHealthy controlsResponse regulatorCellular processesInteraction networkPathogenesis of tuberculosisExosome biogenesisImmune response regulationImmune cell profilesDEGsPotential biomarkersVAMP5Immune cell infiltration analysisGenesTherapeutic targetImmune cellsGlobal health concernDiagnostic performanceVesiclesDisease progressionTreatment outcomesAccurate diagnosis
2014
Highly immunoreactive antibodies against the rHup-F2 fragment (aa 63–161) of the iron-regulated HupB protein of Mycobacterium tuberculosis and its potential for the serodiagnosis of extrapulmonary and recurrent tuberculosis
Sritharan N, Choudhury M, Sivakolundu S, Chaurasia R, Chouhan N, Rao P, Sritharan M. Highly immunoreactive antibodies against the rHup-F2 fragment (aa 63–161) of the iron-regulated HupB protein of Mycobacterium tuberculosis and its potential for the serodiagnosis of extrapulmonary and recurrent tuberculosis. European Journal Of Clinical Microbiology & Infectious Diseases 2014, 34: 33-40. PMID: 25037869, DOI: 10.1007/s10096-014-2203-y.Peer-Reviewed Original ResearchConceptsEnzyme-linked immunosorbent assayTB patientsExtrapulmonary tuberculosisPulmonary tuberculosisHealthy controlsMycobacterium tuberculosisExtrapulmonary TB patientsNormal healthy controlsRecurrent tuberculosisHousehold contactsSerum ironEnhanced immunoreactivityTuberculosisImmunoreactive antibodyAntigenic fragmentsPatientsImmunosorbent assayM. tuberculosisDiagnostic potentialSerumAntigenAntibodiesNegative correlationNegligible levelsHigh levels