Cytotoxicity of the 42 kDa SMase C sphingomyelinase secreted by Leptospira interrogans serovar Pomona on Vero cells.
Chaurasia R, Sritharan M. Cytotoxicity of the 42 kDa SMase C sphingomyelinase secreted by Leptospira interrogans serovar Pomona on Vero cells. Microbiology 2020, 166: 1065-1073. PMID: 32985970, DOI: 10.1099/mic.0.000976.Peer-Reviewed Original ResearchConceptsVero cellsSerovar PomonaHaemorrhagic manifestationsHost cell damageEarly diagnosisSevere formHuman patientsExperimental animalsLeptospira interrogansLeptospirosisCandidate markersSphingomyelinase activityHaemolytic activityPomonaSphingomyelinasePathogenic membersCytotoxicitySphingomyelinase geneActive formHigh levelsCellsPatientsDiagnosisConfocal imagesSphingomyelinases