Abstract 146: Phosphodiesterase 10A Mediates Arterial Calcification Through A P38/MAPK-MMP3 Signaling
Jin Y, Xie Y, Berezowitz A, Davis S, Flores A, Wang X, Guzman R, Cai Y. Abstract 146: Phosphodiesterase 10A Mediates Arterial Calcification Through A P38/MAPK-MMP3 Signaling. Arteriosclerosis Thrombosis And Vascular Biology 2024, 44 DOI: 10.1161/atvb.44.suppl_1.146.Peer-Reviewed Original ResearchVascular smooth muscle cellsChronic kidney diseasePeripheral arterial diseaseArtery calcificationInhibition of PDE10AMedial arterial calcificationVascular calcificationAssociated with increased cardiovascular morbidityCalcifying vascular smooth muscle cellsMatrix metallopeptidaseSmooth muscle cellsVSMCs in vitroCyclic nucleotides cAMPArteries in vivoMMP-3 upregulationCardiovascular morbidityCalcification in vivoArtery diseaseVon Kossa stainingKidney diseaseMuscle cellsRodent modelsVSMC calcificationInducible isoformCalcium assay