Featured Publications
Pressure-Regulated Ventilator Splitting for Disaster Relief: Design, Testing, and Clinical Experience
Raredon MSB, Fisher C, Heerdt PM, Schonberger RB, Nargi A, Nivison S, Fajardo E, Deshpande R, Akhtar S, Greaney AM, Belter J, Raredon T, Zinter J, McKee A, Michalski M, Baevova P, Niklason LE. Pressure-Regulated Ventilator Splitting for Disaster Relief: Design, Testing, and Clinical Experience. Anesthesia & Analgesia 2021, 134: 1094-1105. PMID: 34928890, DOI: 10.1213/ane.0000000000005825.Peer-Reviewed Original ResearchConceptsPositive end-expiratory pressureClinical experienceIndividualized positive end-expiratory pressureIntensive care unitEnd-expiratory pressureCoronavirus disease 2019 (COVID-19) pandemicHealth care teamDisease 2019 pandemicVentilatory supportIll patientsCare unitCare teamVentilator sharingFuture clinical applicationsPatientsIndependent careVentilator capacityClinical applicationCOVID-19 pandemicVentilatorClinical environmentOutline recommendationsMass traumaPandemicHospitalIntubation and Ventilation amid the COVID-19 Outbreak
Meng L, Qiu H, Wan L, Ai Y, Xue Z, Guo Q, Deshpande R, Zhang L, Meng J, Tong C, Liu H, Xiong L. Intubation and Ventilation amid the COVID-19 Outbreak. Anesthesiology 2020, 132: 10.1097/aln.0000000000003296. PMID: 32195705, PMCID: PMC7155908, DOI: 10.1097/aln.0000000000003296.Peer-Reviewed Original ResearchConceptsHigh-flow oxygen therapyPositive airway pressure ventilationCOVID-19Prone position ventilationLung-protective ventilationRapid sequence inductionCOVID-19 outbreakIntubation strategyInvasive ventilationAdequate sedationDisease courseOxygen therapyIll patientsPressure ventilationSequence inductionRapid intubationIntubationVideo laryngoscopeEnhanced riskPatientsVentilation managementVentilationOxygen debtWuhanOutbreakLiver allocation and distribution
Deshpande R, Hirose R, Mulligan D. Liver allocation and distribution. Current Opinion In Organ Transplantation 2017, 22: 162-168. PMID: 28212159, DOI: 10.1097/mot.0000000000000397.Peer-Reviewed Original ResearchConceptsTransplant CommitteeTransplant centersEnd-Stage Liver Disease (MELD) pointsLiver allograft allocationDeceased donor liversLife-saving organsLiver allocation policyAllograft allocationLiver transplantLiver transplantationLiver diseaseDonor liversUnited NetworkDonor organsLiver distributionAdvanced stageLiver allocationOrgan distributionPatient accessTransplantationGeographic disparitiesLiverDisease pointHealthcare systemPatientsRelationship Between Glucose Time in Range in Diabetic and Non-Diabetic Patients and Mortality in Critically Ill Patients
Ammar MA, Ammar AA, Wee T, Deshpande R, Band M, Akhtar S. Relationship Between Glucose Time in Range in Diabetic and Non-Diabetic Patients and Mortality in Critically Ill Patients. Journal Of Intensive Care Medicine 2022, 37: 1625-1633. PMID: 35491687, DOI: 10.1177/08850666221098383.Peer-Reviewed Original ResearchConceptsNon-diabetic patientsBlood glucose rangeDiabetic patientsIll patientsGlucose rangeTIR 70Hospital mortalityMortality rateHospital mortality rateNon-diabetic cohortLower mortality rateAdult patientsCohort studyMortality benefitSingle centerGlucose timePercentage of timeHigh incidencePatientsMortalityDlLtDiabeticsICUHyperglycemiaTreatments Associated with Lower Mortality among Critically Ill COVID-19 Patients: A Retrospective Cohort Study
Zhao X, Gao C, Dai F, Treggiari MM, Deshpande R, Meng L. Treatments Associated with Lower Mortality among Critically Ill COVID-19 Patients: A Retrospective Cohort Study. Anesthesiology 2021, 135: 1076-1090. PMID: 34597362, DOI: 10.1097/aln.0000000000003999.Peer-Reviewed Original ResearchConceptsIll COVID-19 patientsCOVID-19 patientsPropensity score-matched analysisRetrospective cohort studyLower mortalityHospital mortalityCohort studyMultivariable analysisYale New Haven Health SystemIntensive care unit admissionOrgan support treatmentUse of apixabanCare unit admissionSevere COVID-19Intensive care unitCOVID-19 mortalityLower COVID-19 mortalityApixaban treatmentUnit admissionAspirin treatmentCare unitTreatment AssociatedCandidate treatmentSupport treatmentPatientsLiver Transplantation in the Time of COVID19: Barriers and Ethical Considerations for Management and Next Steps
Jaffe A, Schilsky ML, Deshpande R, Batra R. Liver Transplantation in the Time of COVID19: Barriers and Ethical Considerations for Management and Next Steps. Hepatology Communications 2020, 4: 1242-1256. PMID: 32838103, PMCID: PMC7361607, DOI: 10.1002/hep4.1568.Peer-Reviewed Original ResearchEnd-stage liver diseaseLiver transplantLiver transplantationLiver diseaseVirus severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2Syndrome coronavirus 2Critical care bedsLife-saving procedureHealth care systemCorona Virus DiseasePosttransplant recipientsCoronavirus 2Transplant programsTumor controlBlood productsCOVID19 infectionCare bedsPatientsStaff contactTransplantCare systemDisease
2019
Perioperative Hypertensive Urgency After Methylene Blue in a Patient With Undiagnosed Pheochromocytoma
Shukla S, Zhu R, Rubin P, Deshpande R. Perioperative Hypertensive Urgency After Methylene Blue in a Patient With Undiagnosed Pheochromocytoma. A&A Practice 2019, Publish Ahead of Print: &na;. PMID: 30431442, DOI: 10.1213/xaa.0000000000000924.Peer-Reviewed Original ResearchConceptsUndiagnosed pheochromocytomaSurgical intensive care unit admissionIntensive care unit admissionRobotic-assisted laparoscopic hysterectomyMethylene blue administrationCare unit admissionHypertensive urgencyPerioperative hypertensionBlue administrationPerioperative coursePersistent hypertensionPheochromocytoma crisisUnit admissionLaparoscopic hysterectomyAnesthetic careDifferential diagnosisPatientsInvestigative evaluationHypertensionPheochromocytomaHysterectomyAdmissionTumorsDiagnosisAdministration
2015
Management of the Drug Abusing Patient in the ICU
Deshpande R, Gong J, Chadha R, Haddadin A. Management of the Drug Abusing Patient in the ICU. 2015, 389-406. DOI: 10.1007/978-1-4939-1951-2_31.Peer-Reviewed Original Research